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Tiopronin (By mouth)

Tiopronin (tye-oh-PROE-nin)

Prevents kidney stones.

Brand Name(s):

Thiola

There may be other brand names for this medicine.

When This Medicine Should Not Be Used:

You should not use this medicine if you have had an allergic reaction to tiopronin. You should not use this medicine if you have had a blood disorder such as aplastic anemia after using tiopronin. You should not use this medicine if you are pregnant or breast feeding.

How to Use This Medicine:

  • Take your medicine as directed. Your dose may need to be changed several times to find what works best for you.
  • Drink extra fluids so you will urinate more often and help prevent kidney problems.
  • If you awaken during the night to use the bathroom, drink 2 glasses of water before going back to bed.
  • Take this medicine one hour before or two hours after a meal.

If a dose is missed:

  • Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.

How to Store and Dispose of This Medicine:

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.
  • Ask your pharmacist, doctor, or health caregiver about the best way to dispose of any outdated medicine or medicine no longer needed.
  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Make sure your doctor knows if you are also using penicillamine (Cuprimine®, Depen®).

Warnings While Using This Medicine:

  • It is not safe to take this medicine during pregnancy. It could harm an unborn baby. Tell your doctor right away if you become pregnant.
  • Make sure your doctor knows if you have kidney disease, myasthenia gravis, or Goodpasture's syndrome. Make sure your doctor knows if you have any blood disorders such as agranulocytosis, thrombocytopenia, or aplastic anemia.
  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
  • Your doctor will check your progress and the effects of this medicine at regular visits. Keep all appointments.

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Blood in your urine, change in how much and how often you urinate.
  • Chest tightness, coughing up of blood, or trouble breathing.
  • Fever, chills, cough, sore throat, body aches.
  • Lumps in your body such as in armpits, neck, or thighs.
  • Severe muscle weakness.
  • Severe vomiting, diarrhea, or stomach pain.
  • Unusual bleeding, bruising, or weakness.
  • Yellowing of your skin or whites of your eyes.

If you notice these less serious side effects, talk with your doctor:

  • Joint pain or muscle pain.
  • Nausea, mild stomach pain, diarrhea, loss of appetite.
  • Mild skin rash or itching.
  • Reduced taste sensation.
  • Skin changes.

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088


Last Updated: 10/4/2014


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