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Hydromorphone (Rectal)

Hydromorphone (hye-droe-MOR-fone)

Relieves moderate to severe pain. This medicine is a narcotic pain reliever.

Brand Name(s):

There may be other brand names for this medicine.

When This Medicine Should Not Be Used:

You should not use this medicine if you have ever had an allergic reaction to hydromorphone or sulfites. You should not use this medicine if you have certain types of breathing problems, brain tumor, or kyphoscoliosis (spine problem).

How to Use This Medicine:

Suppository

  • Take your medicine as directed.
  • Never take rectal suppositories by mouth.
  • Wash your hands with soap and water before and after using this medicine. Remove the foil or wrapper from the suppository before inserting it.
  • To make the suppository easier to insert, you may use a lubricating gel such as K-Y® Jelly, but do not use petroleum jelly (Vaseline®).
  • Lie on your left side with your left leg straight or slightly bent, and your right knee bent upward. Gently push the pointed end of the suppository into the rectum about 1 inch.
  • Keep lying down for about 15 minutes to keep the suppository from coming out before it melts. Then, wash your hands again.

If a dose is missed:

  • Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.

How to Store and Dispose of This Medicine:

  • You may store the suppositories in the refrigerator, but do not freeze them.
  • Ask your pharmacist, doctor, or health caregiver about the best way to dispose of the used medicine applicator(s), containers, and any leftover medicine after you have finished your treatment. You will also need to throw away old medicine after the expiration date has passed.
  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Make sure your doctor knows if you are using an MAO inhibitor such as Eldepryl®, Marplan®, Nardil®, or Parnate®.
  • Tell your doctor if you drink alcohol or if you are using any medicine that makes you sleepy, such as allergy medicine or narcotic pain medicine.
  • There are many medicines that can interact with hydromorphone. Make sure your doctor knows about all other medicines you are using.
  • Do not drink alcohol while you are using this medicine.

Warnings While Using This Medicine:

  • Make sure your doctor knows if you are pregnant or breast feeding, or if you have any allergies.
  • Tell your doctor if you have asthma, lung disease, or any other breathing problems. Make sure your doctor knows if you have recently had a head injury or surgery.
  • Make sure your doctor knows if you have Addison's disease, seizure disorder, kidney disease, liver disease, gallbladder disease, ulcerative colitis, or underactive thyroid. Your doctor should know if you have problems with urination or an enlarged prostate.
  • Tell your doctor if you have a history of alcohol or drug abuse or mental illness.
  • This medicine may make you drowsy. Avoid driving, using machines, or doing anything else that could be dangerous if you are not alert.
  • This medicine can be habit-forming. Do not use more than your prescribed dose. Call your doctor if you think your medicine is not working.
  • Tell any doctor or dentist who treats you that you are using this medicine. This medicine may affect certain medical test results.
  • Call your doctor if your symptoms do not improve or if they get worse.
  • This medicine may cause constipation, especially with long-term use. Ask your doctor if you should use a laxative to prevent and treat constipation.

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Decrease in how much and how often you urinate or unable to urinate.
  • Fast, slow, uneven, or pounding heartbeat.
  • Lightheadedness or fainting.
  • Muscle movements you cannot control.
  • Severe stomach pain.
  • Shortness of breath, cold sweat, or bluish-colored skin.
  • Tremors or seizure.
  • Severe drowsiness.
  • Shallow breathing.
  • Warmth or redness in your face, neck, hands, or upper chest.

If you notice these less serious side effects, talk with your doctor:

  • Blurred vision.
  • Confusion, agitation, anxiety, or headache.
  • Changes in your mood or behavior.
  • Dry mouth, loss of appetite.
  • Mild stomach pain or constipation.
  • Feeling sleepy or weakness.
  • Mild skin rash or itching.
  • Nausea or vomiting.

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088


Last Updated: 10/4/2014


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