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Tositumomab (Injection)

Tositumomab (tos-IT-too-moe-mab)

Treats non-Hodgkin lymphoma.

Brand Name(s):

There may be other brand names for this medicine.

When This Medicine Should Not Be Used:

Do not receive this medicine if you have had an allergic reaction to tositumomab or if you are pregnant. This medicine will be withdrawn from the United States market on February 20, 2014.

How to Use This Medicine:

Injectable

  • Medicines used to treat cancer are very strong and can have many side effects. Before receiving this medicine, make sure you understand all the risks and benefits. It is important for you to work closely with your doctor during your treatment.
  • Your doctor will prescribe your dose and schedule. This medicine is given through a needle placed in a vein.
  • You will receive this medicine while you are in a hospital or cancer treatment center. A nurse or other trained health professional will give you this medicine.
  • You may also receive medicines to help prevent possible allergic reactions to the injection.

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • This medicine may interfere with vaccines. Ask your doctor before you get a flu shot or any other vaccines.

Warnings While Using This Medicine:

  • This medicine may cause birth defects if either partner is using it during conception or pregnancy. Tell your doctor right away if you or your partner becomes pregnant. Male and female patients should use an effective form of contraception to prevent pregnancy during treatment and for 12 months after treatment.
  • This medicine could cause infertility. Talk with your doctor before using this medicine if you plan to have children.
  • Make sure your doctor knows if you are breastfeeding or if you have kidney disease, blood or bone marrow problems, or thyroid problems.
  • This medicine may make you bleed, bruise, or get infections more easily. Take precautions to prevent illness and injury. Wash your hands often.
  • This medicine may increase your risk for certain types of cancer or thyroid problems. Talk with your doctor about these risks.
  • You will be exposed radiation while you use this medicine. Talk to your doctor if you have concerns about this.
  • Cancer medicines can cause nausea and/or vomiting in most people, sometimes even after receiving medicines to prevent it. Ask your doctor or nurse about other ways to control these side effects.
  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Fever, chills, cough, sore throat, and body aches
  • Lightheadedness, dizziness, or fainting
  • Swelling in your face, hands, ankles, or feet
  • Unusual bleeding, bruising, tiredness, or weakness

If you notice these less serious side effects, talk with your doctor:

  • Nausea
  • Pain, itching, burning, swelling, or a lump under your skin where the needle is placed

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088


Last Updated: 12/4/2014


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