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Laronidase (Injection)

Laronidase (lar-ON-i-dase)

Improves breathing in people with a condition called Hurler or Hurler-Scheie mucopolysaccharidosis I (MPS I).

Brand Name(s):

Aldurazyme

There may be other brand names for this medicine.

When This Medicine Should Not Be Used:

You should not receive this medicine if you have had an allergic reaction to laronidase.

How to Use This Medicine:

Injectable

  • Your doctor will prescribe your dose and schedule. This medicine is given through a needle placed in a vein.
  • A nurse or other health provider will give you this medicine.
  • This medicine is usually given once per week. The medicine is injected slowly and the needle will remain in place for up to 4 hours.
  • You may be given other medicines to keep you from developing a fever or skin reaction to laronidase.

If a dose is missed:

  • You must use this medicine on a fixed schedule. Call your doctor or pharmacist if you miss a dose.

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

Warnings While Using This Medicine:

  • Make sure your doctor knows if you are pregnant or breast feeding.
  • Tell your doctor if you have heart disease or liver disease.

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Chest pain.
  • Dark-colored urine or pale stools.
  • Fever, chills, cough, sore throat, and runny or stuffy nose.
  • Lightheadedness or fainting.
  • Numbness, tingling, or burning pain in your hands, arms, legs, or feet.
  • Swelling in your hands, ankles, or feet.
  • Unusual bleeding, bruising, or weakness.
  • Yellowing of your skin or the whites of your eyes.

If you notice these less serious side effects, talk with your doctor:

  • Muscle tightness or spasms.
  • Pain, itching, burning, swelling, or a lump under your skin where the needle is placed.
  • Warmth or redness in your face, neck, or chest.

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088


Last Updated: 12/4/2014


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