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Desloratadine/pseudoephedrine (By mouth)

Desloratadine (des-lor-A-ta-deen), Pseudoephedrine Sulfate (soo-doe-e-FED-rin SUL-fate)

Treats symptoms of seasonal allergies. This medicine is a combination of an antihistamine and a decongestant.

Brand Name(s):

Clarinex-D, Clarinex-D 24 Hour, Clarinex-D 24HR, Clarinex-D12 Hour

There may be other brand names for this medicine.

When This Medicine Should Not Be Used:

You should not use this medicine if you have had an allergic reaction to desloratadine, pseudoephedrine, or loratadine (Claritin®, Alavert®). Do not use this medicine if you have narrow-angle glaucoma or if you have used an MAO inhibitor (such as Eldepryl®, Marplan®, Nardil®, or Parnate®) in the last 14 days. Tell your doctor if you have severe heart disease, very high blood pressure, or trouble urinating. Make sure your doctor knows about any reaction you have had to other drugs, especially if it involved trouble sleeping, dizziness, weakness, shaking, or changes in your heart rhythm.

How to Use This Medicine:

24 Hour Tablet, 12 Hour Tablet

  • Take your medicine as directed.
  • You may take this medicine with or without food.
  • Swallow the extended-release tablet whole. Do not crush, break, or chew it.

If a dose is missed:

  • Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.

How to Store and Dispose of This Medicine:

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.
  • Ask your pharmacist, doctor, or health caregiver about the best way to dispose of any outdated medicine or medicine no longer needed.
  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Do not use other antihistamine or decongestant medicines, including ones you can buy without a prescription. Some examples of other antihistamines or decongestants are Actifed®, Alavert®, Benadryl®, Chlor-Trimeton®, Claritin®, Sinutab®, or Sudafed®.

Warnings While Using This Medicine:

  • Make sure your doctor knows if you are pregnant or breastfeeding, or if you have kidney disease, liver disease, or diabetes. Tell your doctor if you have high blood pressure, heart disease, high pressure inside your eye (glaucoma), thyroid problems, or problems with your prostate.

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Excessive sleepiness or not being able to stay awake.
  • Fast or pounding heartbeat, chest pain.
  • Lightheadedness, dizziness, or fainting.
  • Seizures or tremors.
  • Severe nervousness or restlessness.

If you notice these less serious side effects, talk with your doctor:

  • Dry mouth.
  • Headache.
  • Tiredness.
  • Trouble sleeping.

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088


Last Updated: 9/4/2014


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