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Synthetic conjugated estrogens, A (By mouth)

Conjugated Estrogens Synthetic A (KON-joo-gay-ted ES-troe-jenz sin-THET-ik A)

Treats symptoms of menopause, such as hot flashes (warmth or redness in your face, neck, arms, or upper chest) and dryness in the vagina.

Brand Name(s):

Cenestin

There may be other brand names for this medicine.

When This Medicine Should Not Be Used:

You should not use this medicine if you have had an allergic reaction to estrogen or if you are pregnant. Do not use this medicine if you have liver disease or certain kinds of cancer, such as breast cancer. You should not use this medicine if you have had a heart attack, stroke, or a problem with blood clots (such as DVT, deep vein thrombosis, or an embolism) in the past year. Do not use this medicine if you have unusual vaginal bleeding that has not been checked by a doctor.

How to Use This Medicine:

Tablet

  • Take your medicine as directed.
  • Read and follow the patient instructions that come with this medicine. Talk to your doctor or pharmacist if you have any questions.

If a dose is missed:

  • Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.

How to Store and Dispose of This Medicine:

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.
  • Ask your pharmacist, doctor, or health caregiver about the best way to dispose of any outdated medicine or medicine no longer needed.
  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Make sure your doctor knows if you are also using medicine for thyroid problems (such as levothyroxine, Synthroid®) or a blood thinner such as warfarin (Coumadin®).

Warnings While Using This Medicine:

  • Make sure your doctor knows if you are breastfeeding, or if you have heart disease, kidney disease, thyroid disease, or a history of cancer or gallbladder problems. Tell your doctor if you have high blood pressure, high triglycerides in your blood, or low levels of calcium. Make sure your doctor knows if you have ever had liver problems caused by estrogen use or during pregnancy. Tell your doctor if you have endometriosis, asthma, diabetes, epilepsy, lupus, or porphyria (an enzyme problem).
  • Taking large amounts of this medicine over long periods of time may increase your risk of some kinds of cancer. This risk may continue even after you stop using the medicine. Talk to your doctor about your personal risks compared with the benefits of this medicine.
  • Using this medicine may increase your risk of blood clots, stroke, or heart attack. This risk may continue even after you stop using the medicine. Talk to your doctor about your personal risks compared with the benefits of this medicine.
  • Make sure any doctor or dentist who treats you knows that you are using this medicine. You may need to stop using this medicine several days before having surgery or any situation where you must rest or not move for a long time.
  • This medicine may affect the results of certain medical tests.
  • This medicine may increase the risk of dementia (loss of some mental abilities, such as memory or judgment) in women over 65 years old. Talk with your doctor about this risk.
  • Your doctor will check your progress and the effects of this medicine at regular visits. Keep all appointments.

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Breast lump.
  • Chest pain, shortness of breath, or coughing up blood.
  • Numbness or weakness in your arm or leg, or on one side of your body.
  • Pain in your lower leg (calf).
  • Sudden or severe headache, problems with vision, speech, or walking.
  • Trouble seeing, double vision, or migraine headache.
  • Unusual vaginal bleeding.

If you notice these less serious side effects, talk with your doctor:

  • Breast pain.
  • Nausea, stomach pain, bloating, vomiting.
  • Spotty vaginal bleeding.

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088


Last Updated: 12/4/2014


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