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Nepafenac (Into the eye)

Nepafenac (ne-PA-fen-ak)

Treats eye pain and inflammation after cataract surgery. This medicine is an NSAID.

Brand Name(s):

Ilevro, Nevanac

There may be other brand names for this medicine.

When This Medicine Should Not Be Used:

You should not use this medicine if you have had an allergic reaction to nepafenac or to any other NSAIDs, such as aspirin, celecoxib, diclofenac, etodolac, ibuprofen, indomethacin, nabumetone, naproxen, piroxicam, rofecoxib, valdecoxib, Advil®, Aleve®, Celebrex®, Ecotrin®, Motrin®, or Voltaren®.

How to Use This Medicine:

Liquid, Drop

  • Take your medicine as directed.
  • Shake the eye drops well just before each use.
  • Wash your hands with soap and water before and after using this medicine.
  • Lie down or tilt your head back. With your index finger, pull down the lower lid of your eye to form a pocket.
  • To use the eye drops: Hold the dropper close to your eye with the other hand. Drop the correct number of drops into the pocket made between your lower lid and eyeball. Gently close your eyes. Place your index finger over the inner corner of your eye for 1 minute. Do not rinse or wipe the dropper or allow it to touch anything, including your eye. Put the cap on the bottle right away. Keep the bottle upright when you are not using it.
  • Keep using this medicine for at least two weeks unless your doctor tells you otherwise.
  • This medicine can be used with other ophthalmic (eye) medicines. Wait at least 5 minutes before using another eye medicine.

If a dose is missed:

  • Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.

How to Store and Dispose of This Medicine:

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.
  • Ask your pharmacist, doctor, or health caregiver about the best way to dispose of the used medicine container and any leftover medicine after you have finished your treatment. You will also need to throw away old medicine after the expiration date has passed.
  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Make sure your doctor knows if you are also using a blood thinner (such as warfarin, Coumadin®).

Warnings While Using This Medicine:

  • Make sure your doctor knows if you are pregnant. Do not use this medicine during the later part of a pregnancy, unless your doctor tells you to.
  • Make sure your doctor knows if you are breastfeeding, or if you have bleeding problems (such as hemophilia), diabetes, or rheumatoid arthritis. Make sure your doctor knows about all eye problems (such as corneal problems, dry eye syndrome) or surgeries you have had.
  • If you hurt your eye or develop an eye infection, talk with your doctor right away. You may need to change your medicine or stop using it.
  • Slow or delayed healing may occur while you or your child are using this medicine. Ask your doctor before using this medicine together with a topical corticosteroid (such as betamethasone, hydrocortisone).
  • Using this medicine may increase risk of having corneal (front part of the eye) problems, including keratitis. Stop using this medicine and check with your eye doctor right away if you or your child have blurred vision, changes in vision, or eye redness, irritation, or pain while using this medicine.
  • Do not use this medicine while you or your child are wearing contact lenses.
  • Call your doctor if your symptoms do not improve or if they get worse.
  • Your doctor will check your progress and the effects of this medicine at regular visits. Keep all appointments.

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Bleeding, pain, itching, redness, or irritation in your eye.
  • Feeling that your eyes are more sensitive to light.
  • No improvement or slow healing of the eyes after surgery.
  • Red or watery eyes, swollen eyelids, or vision problems.

If you notice these less serious side effects, talk with your doctor:

  • Dry eyes.
  • Feeling that something is in your eye.
  • Headache.
  • Nausea or vomiting.
  • Runny or stuffy nose.
  • Sticky feeling in your eye.

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088


Last Updated: 11/4/2014


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