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Tipranavir (By mouth)

Tipranavir (tye-PRAN-a-vir)

Treats human immunodeficiency virus (HIV) infection. HIV causes acquired immune deficiency syndrome (AIDS). Tipranavir does not cure HIV or AIDS. It is used with another drug called ritonavir (Norvir®) to slow down the progress of the disease.

Brand Name(s):

Aptivus

There may be other brand names for this medicine.

When This Medicine Should Not Be Used:

Do not use this medicine if you have had an allergic reaction to tipranavir or ritonavir. You should not use this medicine if you have moderate or severe liver disease. Do not use this medicine together with alfuzosin (Uroxatral®), amiodarone (Cordarone®, Pacenone®), bepridil (Vascor®), cisapride (Propulsid®), ergot medicines (such as dihydroergotamine, ergonovine, ergotamine, methylergonovine, Cafergot®, D.H.E. 45®, Ergomar®, Ergostat®, Migranal®, or Wigraine®), flecainide (Tambocor®), lovastatin (Altocor®, Mevacor®), oral midazolam (Versed®), pimozide (Orap®), propafenone (Rythmol®), quinidine (Cardioquin®, Quinaglute dura®), rifampin (Rifadin®, Rimactane®), sildenafil (Revatio®), simvastatin (Simcor®, Vytorin®, Zocor®), St John's wort, or triazolam (Halcion®). Do not give this medicine to a child younger than 2 years of age.

How to Use This Medicine:

Liquid Filled Capsule, Liquid

  • Take your medicine as directed.
  • You may take this medicine together with ritonavir capsules or oral liquid with or without food. Always take this medicine together with ritonavir tablets with food.
  • Swallow the capsule whole. Do not break, crush, or chew it.
  • Measure the oral liquid medicine with a marked measuring spoon, oral syringe, or medicine cup.
  • Tipranavir is used with ritonavir (Norvir®) to treat HIV infection. Always take these 2 medicines together at the same time, unless your doctor tells you otherwise. Take all other medicines your doctor has prescribed at the right time of day. This will make your medicines work better.
  • Read and follow the patient instructions that come with this medicine. Talk to your doctor or pharmacist if you have any questions.

If a dose is missed:

  • Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.

How to Store and Dispose of This Medicine:

  • When you first bring this medicine home, store the capsules in the refrigerator until you are ready to open the bottle. Once you have opened the medicine bottle, you may store it at room temperature, away from heat, light, or moisture. The medicine is good for up to 60 days after the bottle is opened. After 60 days, throw away any unused capsules and get a new bottle of your medicine.
  • Store the oral liquid at room temperature. Do not refrigerate or freeze. The liquid must be used within 60 days after the bottle is opened.
  • Ask your pharmacist, doctor, or health caregiver about the best way to dispose of any outdated medicine or medicine no longer needed.
  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Make sure your doctor knows if you use a blood thinner (such as warfarin, Coumadin®), fluticasone (Advair®, Flonase®), medicine to treat impotence (such as sildenafil, tadalafil, vardenafil, Cialis®, Levitra®, or Viagra®), medicine to lower cholesterol (such as atorvastatin, rosuvastatin, Crestor®, or Lipitor®), medicine to treat seizures (such as carbamazepine, phenobarbital, phenytoin, valproic acid, Depakene®, Dilantin®, Luminal®, or Tegretol®), or diabetes medicine that you take by mouth (such as glimepiride, glipizide, glyburide, pioglitazone, repaglinide, tolbutamide, Actos®, Avandia®, Diabeta®, Glucophage®, Glucotrol®, or Prandin®).
  • Tell your doctor if you also take other medicines to treat HIV or AIDS (such as abacavir, atazanavir, didanosine, fosamprenavir, lopinavir, saquinavir, zidovudine, Combivir®, Retrovir®, Trizivir®, or Videx®), medicine to treat a fungus infection (such as fluconazole, itraconazole, ketoconazole, voriconazole, Nizoral®, or Sporanox®), medicine to treat depression (such as desipramine, fluoxetine, paroxetine, sertraline, trazodone, Desyrel®, Paxil®, Prozac®, or Zoloft®), certain blood pressure medicines (such as diltiazem, felodipine, nicardipine, nisoldipine, verapamil, Cardene®, Cardizem®, Cardil®, Isoptin SR®, or Plendil®), strong pain medicines (such as meperidine, methadone, Demerol®, or Dolophine®), bosentan (Tracleer®), buprenorphine and naloxone (Buprex®, Suboxone®), clarithromycin (Biaxin®), colchicine (Colcrys®), cyclosporine (Gengraf®, Neoral®, Sandimmune®), disulfiram (Antabuse®), metronidazole (Flagyl®), midazolam injection, omeprazole (Prilosec®), rifabutin (Mycobutin®), salmeterol (Advair®, Serevent®), sirolimus (Rapamune®), tacrolimus (Prograf®), tadalafil (Adcirca?), or vitamin E supplements.
  • Make sure your doctor knows if you also use hormone replacements or birth control pills containing estrogen, such as ethinyl estradiol, Femhrt®, Loestrin®, Ortho-Novum®, or Ovcon®.

Warnings While Using This Medicine:

  • Make sure your doctor knows if you are pregnant or if you have liver disease (including hepatitis B or C), bleeding problems, diabetes, high blood cholesterol, herpes, or autoimmune disorders (such as Graves disease or polymyositis). Tell your doctor if you think you have been exposed to chickenpox while you are using this medicine. Tell your doctor if you are allergic to sulfa medicines (such as sulfamethoxazole/trimethoprim, Bactrim®, Septra®, or Sulfatrim®).
  • Check with your doctor if you have pain or tenderness in the upper stomach, pale stools, dark urine, loss of appetite, nausea, unusual tiredness or weakness, or yellow eyes or skin. These could be symptoms of a serious liver problem.
  • This medicine may increase your risk for bleeding. Make sure your doctor knows if you have a bleeding disorder such as hemophilia or any medical condition that increases your chance of bleeding. Tell your doctor right away if you have any unusual or unexplained bleeding.
  • Your immune system may get stronger when you start taking HIV medicines. Tell your doctor right away if you notice any changes in your health. Sometimes the immune system will start to fight infections that were hidden in your body, such as pneumonia, herpes, or tuberculosis.
  • This medicine will not keep you from giving HIV to others. Always practice safe sex, even if your partner also has HIV. Do not share needles or other items that may have blood or body fluids on them.
  • Do not breastfeed. You can spread HIV or AIDS to your baby through your breast milk.
  • Birth control pills may not work as well while you are using this medicine. To avoid pregnancy, use an additional form of birth control with your pills.
  • This medicine may increase blood sugar levels. Tell your doctor if you have increased hunger or thirst, changes in how much you urinate, or unusual weight loss. Check with your doctor if you notice a change in the results of your blood or urine sugar tests
  • Serious allergic reactions can occur with this medicine. Check with your doctor right away if you have more than one of the following symptoms while using this medicine: blistering or peeling skin, fever or chills, itching, joint or muscle pain, severe rash, red skin lesions, sunburn, throat tightness, or sores, ulcers, or white spots in the mouth or on the lips.
  • This medicine may cause changes in body fat. Tell your doctor if you notice an increased amount of fat in the upper back, neck or chest and stomach area or a loss of fat from the legs, arms, and face.
  • This medicine may make your skin more sensitive to sunlight. Wear sunscreen. Do not use sunlamps or tanning beds.
  • Do not stop using this medicine suddenly. Your doctor will need to slowly decrease your dose before you stop it completely. This is very important because the amount of virus in your blood may increase and become harder to treat.
  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Blister, peeling, or red skin rash
  • Dark-colored urine or pale stools
  • Fever, chills, cough, sore throat, and body aches
  • Increased thirst or hunger
  • Lightheadedness or fainting
  • Nausea, vomiting, loss of appetite, or pain in your upper stomach
  • Sudden or severe headache, or problems with vision, speech, or walking
  • Trouble breathing
  • Unusual bleeding, bruising, or weakness
  • Yellow skin or eyes

If you notice these less serious side effects, talk with your doctor:

  • Diarrhea
  • Headache or tiredness
  • Mild skin rash
  • Weight gain around your neck, upper back, breast, face, or waist

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088


Last Updated: 11/4/2014


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