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Rosiglitazone/glimepiride (By mouth)

Glimepiride (glye-MEP-ir-ide), Rosiglitazone Maleate (roe-zi-GLI-ta-zone MAL-ee-ate)

Treats type 2 diabetes.

Brand Name(s):


There may be other brand names for this medicine.

When This Medicine Should Not Be Used:

This medicine is not right for everyone. Do not use it if you had an allergic reaction to glimepiride, rosiglitazone, or sulfa drugs.

How to Use This Medicine:


  • Take your medicine as directed. Your dose may need to be changed several times to find what works best for you.
  • It is best to take this medicine with food or milk. Take this medicine with the first meal of the day.
  • This medicine should come with a Medication Guide. Ask your pharmacist for a copy if you do not have one.
  • Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.
  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • There are many other drugs that can interact with rosiglitazone and glimepiride. Make sure your doctor knows about all other medicines you are using, including the following:
    • Clonidine
    • Fluconazole
    • Gemfibrozil
    • Miconazole
    • Phenytoin
    • Reserpine
    • Rifampin
    • Beta-blocker
    • NSAID pain or arthritis medicine (including aspirin, celecoxib, diclofenac, ibuprofen, naproxen)
  • If you also take colesevelam, take rosiglitazone/glimepiride at least 4 hours before you take colesevelam.

Warnings While Using This Medicine:

  • Tell your doctor if you are pregnant or breastfeeding, or if you have heart failure, heart or blood vessel disease, or a history of heart attack. Tell your doctor if you have kidney disease, liver disease, edema, macular edema, adrenal or pituitary gland problems, or a G6PD deficiency. Tell your doctor if you drink alcohol.
  • This medicine may cause the following problems:
    • New or worsening heart failure, increased risk of heart or blood vessel problems
    • Macular edema (swelling in the back of the eye)
    • Increased risk for bone fracture
    • Low blood sugar
  • Women: This medicine may cause you to ovulate if you have not gone through menopause yet. This could happen even if you have a history of irregular periods or problems ovulating. Talk to your doctor about effective birth control.
  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Blistering, peeling, red skin rash
  • Blurred vision or other vision changes
  • Chest pain that may spread, trouble breathing, nausea, unusual sweating, faintness
  • Dark urine or pale stools, nausea, vomiting, loss of appetite, stomach pain, yellow skin or eyes
  • Rapid weight gain, swelling in your hands, ankles, or feet
  • Shaking, trembling, sweating, fast or pounding heartbeat, lightheadedness, hunger, confusion

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088

Last Updated: 11/18/2015

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