Medical Services Patients & Visitors Health Information For Medical Professionals Quality About Us
Text Size:  -   +  |  Print Page  |  Email Page

Rosiglitazone/glimepiride (By mouth)

Glimepiride (glye-MEP-ir-ide), Rosiglitazone Maleate (roe-zi-GLI-ta-zone MAL-ee-ate)

Treats type 2 diabetes.

Brand Name(s):

Avandaryl

There may be other brand names for this medicine.

When This Medicine Should Not Be Used:

This medicine is not right for everyone. Do not use it if you had an allergic reaction to glimepiride or rosiglitazone, or if you have severe heart failure.

How to Use This Medicine:

Tablet

  • Take your medicine as directed. Your dose may need to be changed several times to find what works best for you.
  • It is best to take this medicine with food or milk. Take this medicine with the first meal of the day.
  • This medicine should come with a Medication Guide. Ask your pharmacist for a copy if you do not have one.
  • Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.
  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Some foods and medicines can affect how rosiglitazone/glimepiride works. Tell your doctor if you are using the following:
    • Chloramphenicol, gemfibrozil, insulin, isoniazid, mefenamic acid, miconazole, nicotinic acid, phenytoin, probenecid, rifampin
    • A blood thinner (such as warfarin), a beta blocker blood pressure medicine (such as propranolol), a diuretic (water pill), a MAO inhibitor (MAOI), an NSAID pain or arthritis medicine (aspirin, diclofenac, ibuprofen, naproxen, celecoxib), a phenothiazine medicine (such as chlorpromazine, perphenazine, promethazine, prochlorperazine, thioridazine), a steroid medicine (such as hydrocortisone, methylprednisolone, prednisone, prednisolone, dexamethasone), thyroid medicine, birth control pills containing estrogens, or sulfa drugs

Warnings While Using This Medicine:

  • Tell your doctor if you are pregnant or breastfeeding, or if you have heart or blood vessel disease or had a heart attack. Tell your doctor if you have kidney disease, liver disease, edema (fluid retention or swelling), macular edema, adrenal or pituitary gland problems, or G6PD deficiency. Tell your doctor if you get sick, become injured, or need to have surgery.
  • This medicine may cause the following problems:
    • An increased risk of heart or blood vessel problems
    • Liver problems
    • Macular edema (swelling in the back of the eye)
    • An increased risk for bone fracture
    • Low blood sugar
  • Even if you had problems ovulating and had irregular periods in the past, this medicine may cause you to ovulate. If you could become pregnant, you should discuss birth control options with your doctor.
  • Tell any doctor or dentist who treats you that you are using this medicine. This medicine may affect certain medical test results.
  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Blistering, peeling, or red skin rash
  • Blurred vision or other changes in vision
  • Chest pain that may spread to your arms, jaw, back, or neck, trouble breathing, nausea, unusual sweating, faintness
  • Dark urine or pale stools, nausea, vomiting, loss of appetite, stomach pain, yellow skin or eyes
  • Rapid weight gain, swelling in your hands, ankles, or feet
  • Shaking, trembling, sweating, fast or pounding heartbeat, lightheadedness, hunger, confusion
  • Trouble breathing, tiredness, uneven heartbeat, yellow skin or eyes

If you notice these less serious side effects, talk with your doctor:

  • Headache

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088


Last Updated: 10/4/2014


The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed medical professional should be consulted for diagnosis and treatment of any and all medical conditions. Call 911 for all medical emergencies. Links to other sites are provided for information only -- they do not constitute endorsements of those other sites.
Copyright © 1984- Truven Health Analytics. All rights reserved.

Thomson & A.D.A.M
A.D.A.M. content is best viewed in IE9 or above, Fire Fox and chrome browser.