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Omeprazole/sodium bicarbonate (By mouth)

Omeprazole (oh-MEP-ra-zole), Sodium Bicarbonate (SOE-dee-um bye-KAR-bo-nate)

Treats heartburn, stomach ulcers, gastroesophageal reflux disease (GERD), and esophagus damage. Also helps prevent stomach bleeding in critically ill patients

Brand Name(s):

Rite Aid Omeprazole and Sodium Bicarbonate, Zegerid, Zegerid OTC

There may be other brand names for this medicine.

When This Medicine Should Not Be Used:

This medicine is not right for everyone. Do not use it if you had an allergic reaction to omeprazole or sodium bicarbonate.

How to Use This Medicine:

Capsule, Packet

  • Take your medicine as directed.
  • Take this medicine on an empty stomach, at least 1 hour before you eat. Do not stop taking this medicine sooner than your doctor recommends, even if you feel better. Take this medicine only as directed.
    • Powder: Mix the powder with 1 to 2 tablespoons of water in a small cup and drink this mixture right away. Do not mix with other liquids or foods. Refill the cup with more water and drink it to make sure you get all of the medicine.
    • Capsule: Swallow the capsule whole with water. Do not take this medicine with other liquids. Do not break, crush, or chew the capsule. Do not open the capsule and sprinkle the contents into food.
    • Feeding tube: Patients with feeding tubes should not receive food for 3 hours before and 1 hour after receiving this medicine.
      • Open the packet and mix the powder into about 20 mL of water. Stir or shake well. Do not mix with other liquids or foods.
      • Immediately administer the mixture into the feeding tube with an appropriately sized syringe.
      • All 20 mL of the mixture should be flushed through the tube. Refill the container with water, mix in the leftover medicine, and administer it to make sure all of the medicine is given to the patient.
  • Do not substitute the 20-milligram packets or capsules with the 40-milligram packets or capsules.
  • This medicine should come with a Medication Guide. Ask your pharmacist for a copy if you do not have one.
  • Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.
  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Some medicines and foods can affect how this medicine works. Tell your doctor if you use the following:
    • Ampicillin, clarithromycin, clopidogrel, cyclosporine, diazepam, digoxin, disulfiram, ketoconazole, methotrexate, phenytoin, rifampin, St John's wort, tacrolimus, voriconazole
    • A blood thinner (such as warfarin)
    • A diuretic (water pill)
    • An iron supplement
    • Medicine to treat HIV or AIDS, such as atazanavir, nelfinavir, ritonavir, or saquinavir
  • Tell your doctor if you take calcium supplements regularly.

Warnings While Using This Medicine:

  • Tell your doctor if you are pregnant or breastfeeding, or if you have kidney problems (such as Bartter syndrome), liver disease, heart failure, or osteoporosis.
  • Tell your doctor if you are on a low-salt diet. This medicine contains sodium.
  • This medicine may cause hypomagnesemia (low magnesium levels).
  • This medicine can cause diarrhea. Call your doctor if the diarrhea becomes severe, does not stop, or is bloody. Do not take any medicine to stop diarrhea until you have talked to your doctor. Diarrhea can occur 2 months or more after you stop taking this medicine.
  • This medicine may increase your risk of broken bones in the hip, wrist, and spine. This is more likely if you take this medicine more than once a day, or if you use it for 1 year or longer.
  • Call your doctor if your symptoms do not improve or if they get worse.
  • Your doctor will check your progress and the effects of this medicine at regular visits. Keep all appointments.
  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Blistering, peeling, red skin rash
  • Fast, slow, uneven, or pounding heartbeat
  • Nausea, vomiting, weight loss
  • Seizures, muscle spasms or tremors, dizziness
  • Severe diarrhea that does not go away, stomach pain, fever
  • Swelling in your hands, ankles, or feet
  • Unusual bleeding, bruising, or weakness

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088


Last Updated: 4/4/2015


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