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Acetylcysteine/L-methylfolate/methylcobalamin (By mouth)

Acetylcysteine (a-seet-il-SIS-teen), L-Methylfolate (L-meth-il-FOE-late), Methylcobalamin (METH-il-koe-BAL-a-min)

Used as a dietary supplement for patients with or at risk for memory loss, dementia, Alzheimer's disease, or stroke.

Brand Name(s):

Cerefolin NAC, Metafolbic Plus

There may be other brand names for this medicine.

When This Medicine Should Not Be Used:

You should not use this medicine if you have had an allergic reaction to acetylcysteine, L-methylfolate, or methylcobalamin.

How to Use This Medicine:


  • Take your medicine as directed.

If a dose is missed:

  • Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.

How to Store and Dispose of This Medicine:

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.
  • Ask your pharmacist, doctor, or health caregiver about the best way to dispose of any outdated medicine or medicine no longer needed.
  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Make sure your doctor knows if you are using colchicine, cholestyramine, sulfasalazine, colestipol, pyrimethamine, metformin, para-aminosalicylic acid, potassium chloride, nitrous oxide, or nitrates (such as nitroglycerin, Imdur®, Ismo®, or Monoket®). Tell your doctor if you use medicine to treat seizures (such as carbamazepine, fosphenytoin, phenytoin, phenobarbital, primidone, or valproic acid), medicine to treat pain or inflammation (such as ibuprofen, naproxen, Advil®, Aleve®, or Celebrex®), or medicine to treat an infection (such as trimethoprim/sulfamethoxazole, amoxicillin, penicillin, tetracycline, clindamycin, or metronidazole).

Warnings While Using This Medicine:

  • Make sure your doctor knows if you are pregnant or breastfeeding, or if you have blood disease, liver disease, heart disease, kidney stones, a history of peptic ulcer disease, or diabetes.

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Chest pain, shortness of breath, or coughing up blood.
  • Difficulty urinating, pain while urinating, or blood in your urine.
  • Feeling of swelling of the entire body.
  • Numbness or weakness in your arm or leg, or on one side of your body.
  • Pain in the lower back or groin area.
  • Pain in your lower leg (calf).
  • Sudden or severe headache, problems with vision, speech, or walking.

If you notice these less serious side effects, talk with your doctor:

  • Mild headache.
  • Nausea, vomiting, diarrhea, or upset stomach.
  • Skin rash or itching.

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088

Last Updated: 10/4/2014

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