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Hyaluronic acid (On the skin)

Hyaluronic Acid (hye-al-ure-ON-ate AS-id)

Treats certain types of skin sores and infections, including burns, bed sores, wounds from surgery, and skin ulcers caused by diabetes or varicose veins.

Brand Name(s):

Bionect, HyGel, Hylira, Zacare 4%

There may be other brand names for this medicine.

When This Medicine Should Not Be Used:

You should not use this medicine if you have had an allergic reaction to hyaluronic acid.

How to Use This Medicine:

Cream, Gel/Jelly, Spray, Lotion

  • Take your medicine as directed.
  • This medicine is not for long-term use.
  • This medicine is for use on the skin only. Do not get it in your eyes, nose, or mouth. If it does get on these areas, rinse it off right away.
  • Wash your hands with soap and water before and after you use this medicine.
  • Clean the affected skin area just before using this medicine.
  • Apply a thin layer of the medicine to the affected area. Rub it in gently. After applying the medicine, you may cover the skin area with a bandage or dressing unless your doctor tells you otherwise.
  • Shake the aerosol can just before using. Hold the can 3 to 6 inches from the skin and spray for about 2 seconds.
  • Do not inhale this medicine or use it near heat or an open flame. Do not puncture, break, or burn the aerosol can.

If a dose is missed:

  • Apply a dose as soon as you can. If it is almost time for your next dose, wait until then and apply a regular dose. Do not apply extra medicine to make up for a missed dose.

How to Store and Dispose of This Medicine:

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.
  • Ask your pharmacist or doctor how to dispose of the medicine container and any leftover or expired medicine.
  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Do not put cosmetics or skin care products on the treated skin.
  • Do not use this medicine along with skin cleansers containing benzalkonium chloride (Handclens®, Zephiran®) or benzethonium chloride (Bedside-Care®, Microklenz®, Secura® Moisturizing Cleanser).

Warnings While Using This Medicine:

  • Make sure your doctor knows if you are pregnant or breastfeeding.
  • Do not use this medicine to treat a skin problem your doctor has not examined.
  • Call your doctor if your symptoms do not improve or if they get worse.

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing

If you notice these less serious side effects, talk with your doctor:

  • Burning, itching, or redness on treated skin areas.

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088


Last Updated: 12/4/2014


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