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Pioglitazone/glimepiride (By mouth)

Glimepiride (glye-MEP-ir-ide), Pioglitazone Hydrochloride (pye-oh-GLI-ta-zone hye-droe-KLOR-ide)

Treats type 2 diabetes.

Brand Name(s):

Duetact

There may be other brand names for this medicine.

When This Medicine Should Not Be Used:

This medicine is not right for everyone. Do not use it if you had an allergic reaction to glimepiride, pioglitazone, or sulfa drugs, or if you have severe heart failure.

How to Use This Medicine:

Tablet

  • Take your medicine as directed. Your dose may need to be changed several times to find what works best for you.
  • It is best to take this medicine with food or milk. Take this medicine with the first meal of the day.
  • This medicine should come with a Medication Guide. Ask your pharmacist for a copy if you do not have one.
  • Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.
  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Some medicines can affect how pioglitazone/glimepiride works. Tell your doctor if you are using fluconazole, gemfibrozil, miconazole, rifampin, or blood pressure medicines.
  • If you also take colesevelam, take pioglitazone/glimepiride at least 4 hours before you take colesevelam.

Warnings While Using This Medicine:

  • Tell your doctor if you are pregnant or breastfeeding, or if you have kidney problems, liver disease, heart disease, an adrenal or pituitary gland problem, edema, or a history of bladder cancer. Tell your doctor if you recently had a fever, infection, injury, or surgery. Also tell your doctor if you drink alcohol or have a condition called glucose-6-phosphate dehydrogenase (G6PD) deficiency.
  • This medicine may cause the following problems:
    • Higher risk of heart problems
    • Low blood sugar
    • Serious allergic reactions
    • Serious liver problem
    • Increased risk of bladder cancer
    • Macular edema (eye disease)
    • Bone fractures
  • This medicine may cause you to ovulate, even if you have a history of irregular periods or problems ovulating. Talk to your doctor about effective birth control.
  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments. You will also need to check your blood sugar on a regular basis at home.
  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Blistering, peeling, red skin rash
  • Blurred vision or other changes in vision
  • Dark urine or pale stools, nausea, vomiting, loss of appetite, stomach pain, yellow skin or eyes
  • Rapid weight gain, swelling in your hands, ankles, or feet, trouble breathing
  • Red or pink urine, change in how much or how often you urinate, burning or painful urination
  • Shaking, trembling, sweating, fast or pounding heartbeat, lightheadedness, hunger, confusion

If you notice these less serious side effects, talk with your doctor:

  • Diarrhea, mild nausea, or vomiting
  • Fever, chills, cough, runny or stuffy nose, sore throat, and body aches
  • Headache

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088


Last Updated: 11/4/2014


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