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Sitagliptin (By mouth)

Sitagliptin (sit-a-GLIP-tin)

Treats type 2 diabetes.

Brand Name(s):


There may be other brand names for this medicine.

When This Medicine Should Not Be Used:

This medicine is not right for everyone. Do not use it if you had an allergic reaction to sitagliptin.

How to Use This Medicine:


  • Take your medicine as directed. Your dose may need to be changed several times to find what works best for you.
  • This medicine should come with a Medication Guide. Ask your pharmacist for a copy if you do not have one.
  • Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.
  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Some medicines can affect how sitagliptin works. Tell your doctor if you are also using digoxin.

Warnings While Using This Medicine:

  • Tell your doctor if you are pregnant or breastfeeding, or if you have kidney disease or a history of pancreas problems.
  • This medicine may cause the following problems:
    • Pancreas problems
    • Low blood sugar (more likely when used with other medicines to treat diabetes)
    • Kidney problems
  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Blistering, peeling, red skin rash
  • Change in how much or how often you urinate
  • Shaking, trembling, sweating, fast or pounding heartbeat, faintness or lightheadedness, hunger, confusion
  • Sudden and severe stomach pain, nausea, vomiting, fever, and lightheadedness

If you notice these less serious side effects, talk with your doctor:

  • Cough, runny or stuffy nose, sore throat
  • Headache

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088

Last Updated: 10/4/2015

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