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Oxymorphone (By mouth)

Oxymorphone (ox-i-MOR-fone)

Treats moderate to severe pain. This medicine is a narcotic pain reliever.

Brand Name(s):

Opana, Opana ER

There may be other brand names for this medicine.

When This Medicine Should Not Be Used:

Do not use this medicine if you have had an allergic reaction to oxymorphone, morphine, codeine, or other narcotic pain medicines. Do not use this medicine during an asthma attack, or if you have severe asthma, trouble breathing, hypercarbia or hypercapnia (too much carbon dioxide in your blood), or moderate to severe liver disease. Do not use the extended-release tablet if you have paralytic ileus (blockage of the intestine).

How to Use This Medicine:

Tablet, Long Acting Tablet

  • Take your medicine as directed. Your dose may need to be changed several times to find what works best for you.Tell your doctor if your medicine is not helping your pain.
  • An overdose can be dangerous. Follow these directions carefully so you do not get too much medicine at one time.
  • Take this medicine on an empty stomach, at least 1 hour before or 2 hours after a meal.
  • Swallow the extended-release tablet whole, 1 tablet at a time, immediately after you place it in your mouth. Drink enough water to be able to swallow it completely. Do not crush, break, cut, dissolve, lick, or chew it. This could release a life-threatening amount of oxymorphone into your body.
  • If you take the extended-release tablet, part of the tablet may pass into your stools. This is normal and is nothing to worry about.
  • This medicine should come with a Medication Guide. Ask your pharmacist for a copy if you do not have one.

If a dose is missed:

  • Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.

How to Store and Dispose of This Medicine:

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.
  • Flush all leftover oxymorphone medicine down the toilet after you have finished your treatment. Also flush old oxymorphone after the expiration date has passed. This medicine is one of only a few medicines that should be disposed of this way.
  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Make sure your doctor knows if you are using another narcotic pain reliever (such as buprenorphine, butorphanol, nalbuphine, pentazocine, Buprenex®, Nubain®, Stadol®, Talwin®), or a stomach medicine (such as cimetidine, Tagamet®). Tell your doctor if you have used an MAO inhibitor (MAOI) such as Eldepryl®, Marplan®, Nardil®, or Parnate® within the past 14 days.
  • Tell your doctor if you are also using a phenothiazine medicine, such as prochlorperazine, promethazine, Compazine®, Mellaril®, Phenergan®, Thorazine®, Trilafon®. These medicines may be used to treat severe vomiting, coughing, psychiatric problems, or other conditions. Tell your doctor if you are also using other medicines that can cause dry mouth or constipation (such as atropine, dicyclomine, glycopyrrolate, scopolamine, Bentyl®, Robinul®, Transderm Scop®).
  • Tell your doctor if you drink alcohol or if you are using any medicine that makes you sleepy, such as allergy medicine or narcotic pain medicine.
  • Do not drink alcohol while you are using this medicine.

Warnings While Using This Medicine:

  • Make sure your doctor knows if you are pregnant or breastfeeding, or if you have kidney disease, liver disease, heart disease, low blood pressure, Addison disease, enlarged prostate, or problems passing urine. Tell your doctor if you have any problems with your stomach or digestive system, including gallbladder disease or pancreas problems. Tell your doctor if you have low blood volume, severe scoliosis (an abnormal spine curve), a head injury, or seizures. Also make sure your doctor knows if you have a history of drug or alcohol problems or mental or emotional problems.
  • Tell your doctor if you have breathing problems, such as chronic obstructive pulmonary disease (COPD), cor pulmonale, sleep apnea, hypoxia (low oxygen in your blood), or hypercapnia. This medicine may make it hard to breathe.
  • Do not use more of this medicine or take it more often than your doctor tells you to. This can be life-threatening. Symptoms of an overdose include extreme dizziness or weakness, slow heartbeat or breathing, trouble breathing, seizures, and cold, clammy skin. Call your doctor right away if you notice these symptoms.
  • This medicine can be habit-forming. Do not use more than your prescribed dose. Call your doctor if you think your medicine is not working.
  • Make sure any doctor or dentist who treats you knows that you are using this medicine.
  • Do not stop using this medicine suddenly. Your doctor will need to slowly decrease your dose before you stop it completely.
  • This medicine may make you dizzy or drowsy. Avoid driving, using machines, or doing anything else that could be dangerous until you know how this medicine affects you. You may also feel lightheaded when standing suddenly from a sitting or lying position, so get up slowly.
  • This medicine may cause constipation, especially with long-term use. Ask your doctor if you should use a laxative to prevent and treat constipation.
  • It is against the law and dangerous for anyone else to use your medicine. Keep your unused medicine in a safe and secure place so no one can steal it.

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Blue lips, fingernails, or skin
  • Extreme weakness, shallow breathing, sweating, cold or clammy skin
  • Lightheadedness, dizziness, or fainting
  • Seizures
  • Severe constipation or stomach pain
  • Severe sleepiness, trouble waking up, confusion
  • Trouble breathing

If you notice these less serious side effects, talk with your doctor:

  • Decreased appetite
  • Dry mouth
  • Headache
  • Itching skin
  • Mild constipation, diarrhea, nausea, vomiting
  • Sleepiness or trouble sleeping

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088


Last Updated: 7/4/2014


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