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Oxymorphone (By mouth)

Oxymorphone (ox-i-MOR-fone)

Treats moderate to severe pain. This medicine is a narcotic pain reliever.

Brand Name(s):

Opana, Opana ER

There may be other brand names for this medicine.

When This Medicine Should Not Be Used:

This medicine is not right for everyone. Do not use it if you had an allergic reaction to oxymorphone, morphine, codeine, or other narcotic pain medicines, or if you have severe breathing problems, moderate to severe liver disease, or paralytic ileus.

How to Use This Medicine:

Tablet, Long Acting Tablet

  • Take your medicine as directed. Your dose may need to be changed several times to find what works best for you. An overdose can be dangerous. Follow directions carefully so you do not get too much medicine at one time
  • Take this medicine on an empty stomach, at least 1 hour before or 2 hours after a meal.
  • Swallow the extended-release tablet whole. Do not crush, break, or chew it.
  • This medicine should come with a Medication Guide. Ask your pharmacist for a copy if you do not have one.
  • Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.
  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Store the medicine in a safe and secure place. Do not throw unused medicine in the trash. Flush it down the toilet, or take it to a community take-back program if available.

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Some medicines can affect how oxymorphone works. Tell your doctor if you are also using any of the following:
    • Cimetidine
    • A phenothiazine medicine
    • An MAO inhibitor (MAOI) within the past 14 days
  • Tell your doctor if you drink alcohol or if you are using any medicine that makes you sleepy, such as allergy medicine or narcotic pain medicine. Tell your doctor if you are also using buprenorphine, butorphanol, nalbuphine, pentazocine, or a muscle relaxer.
  • Do not drink alcohol while you are using this medicine.

Warnings While Using This Medicine:

  • Tell your doctor if you are pregnant or breastfeeding, or if you have kidney disease, liver disease, lung or breathing problems (such as asthma or COPD), low blood pressure, Addison disease, an enlarged prostate, gallbladder problems, pancreas problems, trouble urinating, or stomach or digestion problems. Also tell your doctor if you have a history of depression, severe scoliosis, head injury, brain tumor, seizures, or drug or alcohol abuse.
  • This medicine may cause the following problems:
    • High risk of overdose, which can lead to death
    • Respiratory depression (serious breathing problem that can be life-threatening)
  • This medicine can be habit-forming. Do not use more than your prescribed dose. Call your doctor if you think your medicine is not working.
  • Do not stop using this medicine suddenly. Your doctor will need to slowly decrease your dose before you stop it completely.
  • This medicine may make you dizzy, drowsy, or faint. Do not drive or do anything else that could be dangerous until you know how this medicine affects you. Sit or lie down if you feel dizzy. Stand up carefully.
  • This medicine may cause constipation, especially with long-term use. Ask your doctor if you should use a laxative to prevent and treat constipation.
  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Blue lips, fingernails, or skin
  • Extreme dizziness or weakness, shallow breathing, slow or uneven heartbeat, sweating, cold or clammy skin, seizures
  • Severe confusion, lightheadedness, dizziness, fainting
  • Severe constipation, stomach pain, or vomiting
  • Trouble breathing or slow breathing

If you notice these less serious side effects, talk with your doctor:

  • Itching skin
  • Mild constipation, nausea, or vomiting
  • Mild sleepiness or tiredness

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088


Last Updated: 10/4/2014


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