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Difluprednate (Into the eye)

Difluprednate (dye-floo-PRED-nate)

Treats eye redness, swelling, and pain caused by eye surgery. Also used to treat eye inflammation or swelling. This medicine is a corticosteroid.

Brand Name(s):

Durezol

There may be other brand names for this medicine.

When This Medicine Should Not Be Used:

Do not use this medicine if you have had an allergic reaction to difluprednate, or if you have certain types of fungus, bacterial, and viral eye infections (such as herpes simplex).

How to Use This Medicine:

Liquid, Drop

  • Take your medicine as directed. Your dose may need to be changed several times to find what works best for you.
  • This medicine is not for long-term use.
  • Wash your hands with soap and water before and after using this medicine.
  • Lie down or tilt your head back. With your index finger, pull down the lower lid of your eye to form a pocket.
  • To use the eye drops: Hold the dropper close to your eye with the other hand. Drop the correct number of drops into the pocket made between your lower lid and eyeball. Gently close your eyes. Place your index finger over the inner corner of your eye for 1 minute. Do not rinse or wipe the dropper or allow it to touch anything, including your eye. Put the cap on the bottle right away. Keep the bottle upright when you are not using it.
  • Do not touch the eye dropper tip to any surface. This will help keep the medicine free of germs.
  • If you are using this medicine after an eye surgery, use a separate bottle for each eye. Use of the same bottle of eye drops for both eyes is not recommended.
  • Remove contact lenses before you put the drops in your eyes. Wait at least 10 minutes after you use this medicine before you put your contact lenses back in.

If a dose is missed:

  • Apply a dose as soon as you can. If it is almost time for your next dose, wait until then and apply a regular dose. Do not apply extra medicine to make up for a missed dose.

How to Store and Dispose of This Medicine:

  • Store the eye drop bottle in the protective carton at room temperature, away from heat, moisture, and direct light. Do not freeze.
  • Ask your pharmacist, doctor, or health caregiver about the best way to dispose of the used medicine container and any leftover medicine after you have finished your treatment. You will also need to throw away old medicine after the expiration date has passed.
  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

Warnings While Using This Medicine:

  • Make sure your doctor knows if you are pregnant or breastfeeding, if you have any other eye problem (such as glaucoma or an infection), or if you have recently had cataract surgery.
  • This medicine may increase the pressure inside your eye (glaucoma) or cause posterior subcapsular cataracts (a rare type of cataract). Slow or delayed healing may also occur if you are using this medicine after cataract surgery. You will need regular eye exams to check for these problems.
  • If you hurt your eye, develop an eye infection, or need to have eye surgery, talk with your doctor right away. You may need to change your medicine or stop using it.
  • Call your doctor if your symptoms do not improve or if they get worse.

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Blurred vision, changes in vision
  • Burning, itching, redness, soreness of the eye
  • Sensitivity of the eyes to light
  • Throbbing eye pain

If you notice these less serious side effects, talk with your doctor:

  • Feeling of having something in the eye
  • Watering of the eyes

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088


Last Updated: 10/4/2014


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