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Milnacipran (By mouth)

Milnacipran (mil-NA-si-pran)

Treats fibromyalgia.

Brand Name(s):

Savella, Savella Titration Pack

There may be other brand names for this medicine.

When This Medicine Should Not Be Used:

This medicine is not right for everyone. Do not use it if you have an uncontrolled narrow-angle glaucoma.

How to Use This Medicine:

Tablet

  • Take your medicine as directed. Your dose may need to be changed several times to find what works best for you.
  • This medicine should come with a Medication Guide. Ask your pharmacist for a copy if you do not have one.
  • Missed dose: If you miss a dose, skip the missed dose and take your next dose at your regularly scheduled time.
  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Do not use this medicine if you have used an MAO inhibitor (MAOI) (including linezolid or methylene blue injection) within the past 14 days. Do not take an MAO inhibitor for at least 5 days after stopping this medicine.
  • Tell your doctor if you are using St John's wort, buspirone, clomipramine, clonidine, digoxin, epinephrine, fentanyl, lithium, norepinephrine, tramadol, or tryptophan supplements.
  • Tell your doctor if you are using medicine to treat depression, medicine to treat migraine headaches, an NSAID pain or arthritis medicine (such as aspirin, celecoxib, ibuprofen, naproxen), a diuretic or water pill, or a blood thinner (such as warfarin).
  • Tell your doctor if you drink alcohol or if you are using any medicine that makes you sleepy, such as allergy medicine or narcotic pain medicine.

Warnings While Using This Medicine:

  • Tell your doctor if you are pregnant or breastfeeding, or if you have kidney disease, liver disease, heart disease, heart rhythm problems, high blood pressure, glaucoma, an enlarged prostate, or a history of painful or difficult urination. Also tell your doctor if you have a history of seizures, depression, or mania.
  • This medicine may cause the following problems:
    • Serotonin syndrome
    • High blood pressure
    • Liver problems
    • Hyponatremia (low sodium levels)
    • Higher risk of bleeding problems (especially if used with a blood thinner or NSAID medicine)
  • For some children, teenagers, and young adults, this medicine can increase thoughts of suicide. Tell your doctor right away if you start to feel more depressed or think about hurting yourself.
  • This medicine may make you drowsy or less alert. Do not drive or do anything else that could be dangerous until you know how this medicine affects you.
  • Do not stop using this medicine suddenly. Your doctor will need to slowly decrease your dose before you stop it completely.
  • Your doctor will check your progress and the effects of this medicine at regular visits. Keep all appointments. Your blood pressure and heart rate will also be monitored while you use this medicine.
  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Anxiety, restlessness, fever, sweating, muscle spasms, nausea, vomiting, diarrhea, seeing or hearing things that are not there
  • Blistering, peeling, red skin rash
  • Confusion, weakness, and muscle twitching
  • Dark urine or pale stools, nausea, vomiting, loss of appetite, pain in your upper stomach, yellow skin or eyes
  • Fast, pounding, or uneven heartbeat or pulse
  • Increased energy, racing thoughts, reckless behavior, talking more than usual
  • Seizures or tremors
  • Unusual behavior or thoughts about hurting yourself or others
  • Unusual bleeding or bruising

If you notice these less serious side effects, talk with your doctor:

  • Constipation, nausea, vomiting
  • Increased sweating
  • Mild headache or dizziness
  • Problems with urination or sex
  • Warmth or redness in your face, neck, arms, or upper chest

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088


Last Updated: 8/4/2014


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