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Dexlansoprazole (By mouth)

Dexlansoprazole (dex-lan-SOE-pra-zole)

Treats heartburn, gastroesophageal reflux disease (GERD), or a damaged esophagus. This medicine is a proton pump inhibitor (PPI).

Brand Name(s):

Dexilant

There may be other brand names for this medicine.

When This Medicine Should Not Be Used:

This medicine is not right for everyone. Do not use it if you had an allergic reaction to dexlansoprazole.

How to Use This Medicine:

Delayed Release Capsule

  • Take this medicine as directed. You may need to take it for several weeks before you feel better.
  • Swallow the capsule whole. Do not chew.
  • If you cannot swallow the capsule, you may use one of the methods listed below.
  • Applesauce:
    • 1. Open the capsule and pour the medicine into 1 tablespoon of applesauce.
    • 2. Swallow the mixture right away. Do not chew it.
  • Oral syringe:
    • 1. Open the capsule and combine the medicine with 20 milliliters (mL) of water in a clean container.
    • 2. Use an oral syringe to draw up the water and medicine mixture.
    • 3. Swirl the syringe gently so the medicine stays mixed in the water.
    • 4. Give the mixture directly into the mouth right away. Do not chew.
    • 5. Refill the syringe with 10 mL of water. Swirl gently. Swallow the water. This will make sure you get your whole dose.
    • 6. Repeat step 5 with another 10 mL of water.
  • Feeding tube:
    • 1. Open the capsule and combine the medicine with 20 milliliters (mL) of water in a clean container.
    • 2. Use a catheter-tip syringe to draw up the water and medicine mixture.
    • 3. Swirl the syringe gently so the medicine stays mixed in the water.
    • 4. Inject the medicine into the feeding tube right away.
    • 5. Refill the syringe with 10 mL of water. Swirl it gently. Inject the water into the tube to rinse any leftover medicine through the tube.
    • 6. Repeat step 5 with another 10 mL of water.
  • This medicine should come with a Medication Guide. Ask your pharmacist for a copy if you do not have one.
  • Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.
  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Do not use this medicine together with atazanavir.
  • Dexlansoprazole affects digestion and may keep other medicines from working correctly. Tell your doctor if you are using any of the following:
    • Ampicillin, digoxin, erlotinib, ketoconazole, methotrexate, mycophenolate mofetil, tacrolimus
    • Blood thinner (such as warfarin)
    • Diuretic (water pill)
    • Iron supplements

Warnings While Using This Medicine:

  • Tell your doctor if you are pregnant or breastfeeding, or if you have liver disease or osteoporosis.
  • This medicine may cause the following problems:
    • Serious kidney problems
    • Low vitamin B12 levels in the blood
    • Broken bones in the hip, wrist, or spine
    • Low magnesium levels in the blood
  • This medicine can cause diarrhea. Call your doctor if the diarrhea becomes severe, does not stop, or is bloody. Do not take any medicine to stop diarrhea until you have talked to your doctor. Diarrhea can occur 2 months or more after you stop taking this medicine.
  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Blistering, peeling, red skin rash
  • Fast, pounding, or uneven heartbeat
  • Fever, joint pain, swelling in your body, unusual weight gain, changes in how much or how often you urinate
  • Seizures, dizziness, muscle cramps, or twitching
  • Severe diarrhea that does not go away, stomach pain, nausea, vomiting, and fever

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088


Last Updated: 7/4/2015


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