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Adapalene/benzoyl peroxide (On the skin)

Adapalene (a-DAP-a-leen), Benzoyl Peroxide (BEN-zoe-il per-OX-ide)

Treats acne.

Brand Name(s):

Epiduo

There may be other brand names for this medicine.

When This Medicine Should Not Be Used:

You should not use this medicine if you have had an allergic reaction to adapalene or benzoyl peroxide.

How to Use This Medicine:

Gel/Jelly

  • Take your medicine as directed.
  • Read and follow the patient instructions that come with this medicine. Talk to your doctor or pharmacist if you have any questions.
  • Use this medicine only on your skin. Rinse it off right away if it gets on a cut or scrape. Do not get the medicine in your eyes, nose, or mouth.
  • Wash your hands with soap and water before and after you use this medicine.
  • Before applying this medicine, wash your skin with water and a mild soap. Rinse well and pat dry.
  • Apply a thin layer of the medicine to the affected area. Rub it in gently.
  • You may need to use this medicine for several weeks or months before your skin starts to look better. Applying extra medicine will not make it work faster.

If a dose is missed:

  • Apply a dose as soon as you can. If it is almost time for your next dose, wait until then and apply a regular dose. Do not apply extra medicine to make up for a missed dose.

How to Store and Dispose of This Medicine:

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.
  • Ask your pharmacist or doctor how to dispose of the medicine container and any leftover or expired medicine.
  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Do not use any other medicines on the treated skin areas without asking your doctor. Avoid using any skin care products that can dry or irritate your skin. These include rough skin cleansers, hair removal products, soaps or cosmetics that cause dryness, or products that contain alcohol, astringents, spices, or lime.

Warnings While Using This Medicine:

  • Make sure your doctor knows if you are pregnant or breastfeeding.
  • This medicine may make your skin more sensitive to sunlight, wind, and cold weather. Use a sunscreen when you are outdoors. Avoid sunlamps and tanning beds. You may need to wear protective clothing, such as a hat.
  • Skin reactions such as dryness, redness, scaling, burning, or stinging can occur when you use this medicine. Use a moisturizer as needed to lessen these skin problems.
  • Do not use "waxing" as a hair removal method on skin areas treated with this medicine.
  • Allow this medicine to dry completely before getting dressed. This medicine may cause bleaching of clothes or hair.
  • Do not use this medicine to treat a skin problem your doctor has not examined. Do not use this medicine if you have a sunburn or eczema.
  • Your doctor will check your progress and the effects of this medicine at regular visits. Keep all appointments.

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Blistering, burning, crusting, dryness, or flaking of the skin.
  • Severe redness or swelling of the skin.

If you notice these less serious side effects, talk with your doctor:

  • Mild burning or stinging sensation.

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088


Last Updated: 4/4/2014
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