Medical Services Patients & Visitors Health Information For Medical Professionals Quality About Us
Text Size:  -   +  |  Print Page  |  Email Page

Amlodipine/valsartan/hydrochlorothiazide (By mouth)

Amlodipine Besylate (am-LOE-di-peen BES-i-late), Hydrochlorothiazide (hye-droe-klor-oh-THYE-a-zide), Valsartan (val-SAR-tan)

Treats high blood pressure. This medicine contains a calcium channel blocker (CCB), an angiotensin receptor blocker (ARB), and a thiazide diuretic (water pill).

Brand Name(s):

Exforge HCT

There may be other brand names for this medicine.

When This Medicine Should Not Be Used:

This medicine is not right for everyone. Do not take it if you had an allergic reaction to amlodipine, valsartan, hydrochlorothiazide, or a sulfonamide (sulfa drug), or if you are pregnant or not able to urinate.

How to Use This Medicine:

Tablet

  • Take your medicine as directed. Your dose may need to be changed several times to find what works best for you.
  • Read and follow the patient instructions that come with this medicine. Talk to your doctor or pharmacist if you have any questions.
  • Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.
  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Do not use this medicine together with aliskiren if you have diabetes.
  • Some medicines can affect how this medicine works. Tell your doctor if you are taking any of the following:
    • Atropine, biperiden
    • Cancer medicine (cyclophosphamide, methotrexate)
    • Carbamazepine
    • Cholesterol medicine (cholestyramine, colestipol)
    • Cyclosporine
    • Digoxin
    • Diuretic medicine (water pill), such as amiloride, spironolactone, triamterene
    • HIV/AIDS medicine, such as ritonavir
    • Infection medicine, such as clarithromycin, itraconazole, ketoconazole, telithromycin
    • Insulin or an oral diabetes medicine, such as glimepiride, glyburide, metformin
    • Lithium
    • NSAID pain or arthritis medicine, such as aspirin, diclofenac, ibuprofen, naproxen
    • Rifampin
    • Simvastatin
    • Steroid medicine
  • Ask your doctor before you use any medicine, supplement, or salt substitute that contains potassium.
  • Tell your doctor if you drink alcohol or if you are using any medicine that makes you sleepy, such as allergy medicine or narcotic pain medicine.

Warnings While Using This Medicine:

  • It is not safe to take this medicine during pregnancy. It could harm an unborn baby. Tell your doctor right away if you become pregnant.
  • Tell your doctor if you are breastfeeding or if you have kidney problems, liver disease, heart or blood vessel disease (including heart failure or a history of a heart attack), diabetes, gout, high cholesterol levels, gallstones, or lupus. Tell your doctor if you have a mineral imbalance (such as high or low calcium, potassium, or sodium levels) or a history of asthma, allergies, or angioedema.
  • This medicine may cause the following problems:
    • Glaucoma
    • Kidney problems
    • High potassium levels
    • Worsening symptoms of an existing heart problem
  • This medicine could lower your blood pressure too much, especially when you first use it or if you are dehydrated. Stand or sit up slowly if you feel dizzy or lightheaded.
  • Do not stop taking this medicine without asking your doctor, even if you feel well. This medicine will not cure your high blood pressure, but it will help keep it in a normal range. You may have to take blood pressure medicine for the rest of your life.
  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Blistering, peeling, red skin rash
  • Change in how much or how often you urinate, painful urination
  • Chest pain that spreads to your arms, jaw, back, or neck, trouble breathing, nausea, unusual sweating, fainting
  • Confusion, weakness, uneven heartbeat, numbness or tingling in your hands, feet, or lips
  • Dry mouth, increased thirst, muscle cramps, nausea or vomiting, uneven heartbeat
  • Lightheadedness, dizziness, or fainting
  • Joint pain
  • Rapid weight gain, swelling in your hands, ankles, or feet
  • Vision changes or eye pain

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088


Last Updated: 10/4/2014


The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed medical professional should be consulted for diagnosis and treatment of any and all medical conditions. Call 911 for all medical emergencies. Links to other sites are provided for information only -- they do not constitute endorsements of those other sites.
Copyright © 1984- Truven Health Analytics. All rights reserved.

Thomson & A.D.A.M
A.D.A.M. content is best viewed in IE9 or above, Fire Fox and chrome browser.