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Telmisartan/amlodipine (By mouth)

Amlodipine Besylate (am-LOE-di-peen BES-i-late), Telmisartan (tel-mi-SAR-tan)

Treats high blood pressure. A lower blood pressure can reduce the risk of stroke and heart attack. This medicine contains an angiotensin receptor blocker (ARB) and a calcium channel blocker (CCB).

Brand Name(s):

Twynsta

There may be other brand names for this medicine.

When This Medicine Should Not Be Used:

Do not use this medicine if you have had an allergic reaction to telmisartan or amlodipine, or if you are pregnant. Do not use this medicine together with aliskiren (Tekturna®) if you have diabetes.

How to Use This Medicine:

Tablet

  • Take your medicine as directed. Your dose may need to be changed several times to find what works best for you.
  • This medicine works best when you take it at the same time every day and do not miss any doses.
  • Carefully follow your doctor's instructions about any special diet.Drink plenty of fluids if you exercise, sweat more than usual, or have diarrhea or vomiting.
  • Read and follow the patient instructions that come with this medicine. Talk to your doctor or pharmacist if you have any questions.

If a dose is missed:

  • Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.

How to Store and Dispose of This Medicine:

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Do not remove a tablet from the blister pack until you are ready to take your medicine.
  • Ask your pharmacist, doctor, or health caregiver about the best way to dispose of any outdated medicine or medicine no longer needed.
  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Make sure your doctor knows if you also use other medicine for high blood pressure (such as aliskiren (Tekturna®), enalapril, lisinopril, ramipril, Lotrel®, Zestril®) or a diuretic (water pill, such as amiloride, furosemide, hydrochlorothiazide, spironolactone, torsemide, triamterene, Aldactone®, Demadex®, Lasix®).
  • Make sure your doctor knows if you also use digoxin (Digitek®, Lanoxicaps®, Lanoxin®), diltiazem (Cardizem®), lithium (Eskalith®, Lithobid®), ritonavir (Norvir®), simvastatin (Vytorin®, Zocor®), St John's wort, medicine to treat an infection (such as itraconazole, ketoconazole, rifampicin, Nizoral®, Rifadin®, Rimactane®), medicine to treat seizures (such as carbamazepine, fosphenytoin, phenobarbital, phenytoin, primidone, Dilantin®, Tegretol®), or an NSAID pain or arthritis medicine (such as aspirin, diclofenac, ibuprofen, naproxen, Advil®, Aleve®, Celebrex®, Voltaren®).
  • Ask your doctor before you use any medicine, supplement, or salt substitute that contains potassium.

Warnings While Using This Medicine:

  • It is not safe to take this medicine during pregnancy. It could harm an unborn baby. Tell your doctor right away if you become pregnant.
  • Make sure your doctor knows if you are breastfeeding, or if you have kidney problems, liver disease, angina, congestive heart failure, heart or blood vessel problems, a recent heart attack, or a mineral imbalance (such as high potassium or low sodium in the blood).
  • This medicine could lower your blood pressure too much and cause you to feel dizzy or lightheaded. Stand or sit up slowly if you are dizzy. This is more likely to happen when you begin to use the medicine or if you become dehydrated.
  • Call your doctor right away if you have chest pain that is worse than usual; trouble breathing; nausea or vomiting; pain or discomfort in your arms, jaw, back, or neck; fainting; or unusual sweating. This medicine may worsen the symptoms of an existing heart problem.
  • Do not stop using this medicine without asking your doctor, even if you feel well. This medicine will not cure your high blood pressure, but it will help keep it in the normal range. You may have to take blood pressure medicine for the rest of your life.
  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Change in how much or how often you urinate
  • Chest pain that may spread to your arms, jaw, back, or neck, trouble breathing, nausea, unusual sweating
  • Confusion, weakness, uneven heartbeat, trouble breathing, numbness or tingling in your hands, feet, or lips
  • Fast, pounding, or uneven heartbeat
  • Lightheadedness, dizziness, fainting
  • Rapid weight gain, swelling in your hands, ankles, or feet

If you notice these less serious side effects, talk with your doctor:

  • Cough, stuffy or runny nose, sore throat

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088


Last Updated: 7/4/2014


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