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Collagenase, clostridium histolyticum (Injection)

Collagenase, Clostridium histolyticum (KOL-a-jen-ase klos-TRID-ee-um his-toe-LIT-ik-um)

Treats Dupuytren contracture and Peyronie disease.

Brand Name(s):

Xiaflex

There may be other brand names for this medicine.

When This Medicine Should Not Be Used:

This medicine is not right for everyone. You should not receive it if you had an allergic reaction to collagenase, Clostridium histolyticum, or if you have Peyronie plaque in the penile urethra.

How to Use This Medicine:

Injectable

  • Your doctor will prescribe your exact dose and tell you how often it should be given. This medicine is given as a shot into your hand or penis.
  • A nurse or other health provider will give you this medicine.
  • This medicine should come with a Medication Guide. Ask your pharmacist for a copy if you do not have one.

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Some medicines can affect how collagenase, Clostridium histolyticum works. Tell your doctor if you are using blood thinners, such as high-dose aspirin or warfarin.

Warnings While Using This Medicine:

  • Tell your doctor if your are pregnant or breastfeeding, or if you have a blood clotting problem.
  • This medicine may cause the following problems:
    • Tendon rupture or other serious injury to the affected finger or hand
    • Fracture of or other serious injury to the penis
    • Bleeding or bruising at the injection site
  • Your doctor will check your progress and the effects of this medicine at regular visits. Keep all appointments.

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Blood in the urine, trouble urinating (Peyronie disease)
  • Fever or chills
  • Popping sound or sensation in an erect penis (Peyronie disease)
  • Rapid weight gain, swelling of your hands, ankles, or feet
  • Severe bruising or bleeding at the injection site
  • Sudden loss of an erection or painful erection (Peyronie disease)

If you notice these less serious side effects, talk with your doctor:

  • Redness, pain, itching, bleeding, swelling, or tenderness at or around the injection site
  • Swollen, painful, or tender glands in your neck or armpit

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088


Last Updated: 9/4/2014


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