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Ketorolac (Into the nose)

Ketorolac Tromethamine (kee-toe-ROLE-ak troe-METH-a-meen)

Relieves moderate to severe pain. This medicine is a nonsteroidal anti-inflammatory drug (NSAID).

Brand Name(s):


There may be other brand names for this medicine.

When This Medicine Should Not Be Used:

This medicine is not right for everyone. Do not use it if you had an allergic reaction to ketorolac or ethylenediamine tetraacetic acid (EDTA). Do not use it if you have a history of aspirin-sensitive asthma, aspirin sensitivity, or you had an allergic reaction to another NSAID medicine. Do not use this medicine if you have a stomach ulcer, a bleeding disorder, or you are pregnant or breastfeeding.

How to Use This Medicine:


  • Take your medicine as directed.
  • This medicine is for use only in the nose. Do not get any of it in your eyes or on your skin. If it does get on these areas, rinse it off right away.
  • If you are using the nasal spray for the first time, you will need to prime the spray. To do this, pump the bottle 5 times until some of the medicine sprays out. Each bottle is for single-day use.
  • Before using the medicine, gently blow your nose to clear the nostrils.
  • After using the nasal spray, wipe the tip of the bottle with a clean tissue and put the cap back on.
  • This medicine is not for long-term use. Do not use it for more than 5 days in a row.
  • Drink extra fluids so you will urinate more often and help prevent kidney problems.
  • Read and follow the patient instructions that come with this medicine. Talk to your doctor or pharmacist if you have any questions.
  • Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.
  • Keep the unopened bottle in the refrigerator. Once opened, store the bottle at room temperature, away from heat and direct sunlight. Throw away any unused medicine 24 hours after you opened the bottle and used your first dose. Do this even if some medicine remains in the bottle.

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Do not use this medicine if you are also using pentoxifylline or probenecid.
  • Do not use any other forms of ketorolac (such as injection or tablets) or other NSAIDs unless your doctor says it is okay. Some other NSAIDs are aspirin, diclofenac, ibuprofen, or naproxen.
  • Some medicines can affect how ketorolac works. Tell your doctor if you are using lithium, methotrexate, thiothixene, or alprazolam.
  • Also tell your doctor if you are using a blood thinner (such as warfarin), a steroid medicine, a diuretic or "water pill" (such as furosemide, hydrochlorothiazide [HCTZ], torsemide), blood pressure medicine (such as enalapril, lisinopril, losartan), medicine to treat depression (such as fluoxetine), or medicine for seizures (such as carbamazepine or phenytoin).

Warnings While Using This Medicine:

  • Tell your doctor if you have kidney disease, liver disease, anemia, Crohn disease, ulcerative colitis or a history of stomach ulcers, high blood pressure, asthma, congestive heart failure, or other heart or circulation problems.
  • This medicine may cause the following problems:
    • Bleeding in your stomach or intestines
    • Higher risk of heart attack or stroke
    • Serious skin reactions
    • Liver problems
  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Blistering, peeling, or red skin rash
  • Bloody or black, tarry stools
  • Change in how much or how often you urinate
  • Chest pain that may spread, trouble breathing, nausea, unusual sweating, fainting
  • Dark urine or pale stools, nausea, vomiting, loss of appetite, stomach pain, yellow skin or eyes
  • Numbness or weakness on one side of your body, sudden or severe headache, problems with vision, speech, or walking
  • Pain in your lower leg (calf)
  • Rapid weight gain, swelling in your hands, ankles, or feet
  • Unusual bleeding, bruising, or weakness
  • Vomiting of blood or material that looks like coffee grounds

If you notice these less serious side effects, talk with your doctor:

  • Constipation, diarrhea, heartburn, stomach pain, or upset stomach
  • Dizziness or drowsiness
  • Nasal discomfort or irritation

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088

Last Updated: 7/4/2014

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