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Acyclovir/hydrocortisone (On the skin)

Acyclovir (ay-SYE-kloe-vir), Hydrocortisone (hye-droe-KOR-ti-sone)

Treats herpes labialis (cold sores). Also helps the cold sores to heal faster.

Brand Name(s):

Xerese

There may be other brand names for this medicine.

When This Medicine Should Not Be Used:

You should not use this medicine if you have had an allergic reaction to acyclovir or hydrocortisone.

How to Use This Medicine:

Cream

  • Take your medicine as directed.
  • This medicine is only for use on the lips and around the mouth. Do not get it in your eyes, inside your mouth or nose, or on the genital area. If the cream does get on these areas, rinse it off with water right away.
  • Wash your hands with soap and water before and after you use this medicine.
  • Clean and dry the affected area before applying this medicine.
  • Apply a thin layer to the affected area that covers the cold sore.
  • Do not rub the cream into the cold sore. Rubbing may spread the virus to other areas around your mouth or make your cold sore worse.
  • Do not cover the treated area with a bandage unless directed by your doctor.
  • Do not bathe, shower, or swim until 30 minutes after applying the medicine.
  • Take all of the medicine in your prescription to clear up your infection, even if you feel better after the first few doses.
  • Read and follow the patient instructions that come with this medicine. Talk to your doctor or pharmacist if you have any questions.

If a dose is missed:

  • Apply a dose as soon as you can. If it is almost time for your next dose, wait until then and apply a regular dose. Do not apply extra medicine to make up for a missed dose.

How to Store and Dispose of This Medicine:

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.
  • Ask your pharmacist or doctor how to dispose of the medicine container and any leftover or expired medicine.
  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Do not put cosmetics or skin care products on the treated skin.

Warnings While Using This Medicine:

  • Make sure your doctor knows if you are pregnant or breastfeeding, or if you have a weak immune system.
  • Do not use this medicine to treat a skin problem your doctor has not examined.
  • Call your doctor if your symptoms do not improve or if they get worse.

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Drying or flaking of the skin.
  • Itching, redness, swelling, burning, or stinging of your skin where the cream is applied.

If you notice these less serious side effects, talk with your doctor:

  • Changes in skin color where the cream is applied.

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088


Last Updated: 4/4/2014
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