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Cabazitaxel (Injection)

Cabazitaxel (ka-baz-i-TAX-el)

Used together with prednisone (a steroid medicine) to treat prostate cancer. This is an antineoplastic agent.

Brand Name(s):

Jevtana

There may be other brand names for this medicine.

When This Medicine Should Not Be Used:

You should not use this medicine if you have had an allergic reaction to cabazitaxel or polysorbate 80. Women and children should not use this medicine.

How to Use This Medicine:

Injectable

  • Medicines used to treat cancer are very strong and can have many side effects. Before receiving this medicine, make sure you understand all the risks and benefits. It is important for you to work closely with your doctor during your treatment.
  • You will receive this medicine while you are in a hospital or cancer treatment center. A nurse or other trained health professional will give you this medicine.
  • Your doctor will prescribe your dose and schedule. This medicine is given through a needle placed in a vein.
  • This medicine is usually given every three weeks and taken together with oral prednisone. Your doctor will tell you how much medicine to take and how often.
  • You may also receive other medicines to help prevent allergic reactions and nausea from the injection.

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Make sure your doctor knows if you are also using St. John's wort, medicine to treat an infection (such as clarithromycin, telithromycin, Biaxin®, or Ketek®), medicine to treat a fungus infection (such as itraconazole, ketoconazole, voriconazole, Nizoral®, Sporanox®, or Vfend®), medicine to treat depression (such as nefazodone or Serzone®), medicine to treat HIV or AIDS (such as atazanavir, indinavir, nelfinavir, ritonavir, saquinavir, Crixivan®, Fortovase®, Invirase®, Norvir®, Reyataz®, or Viracept®), medicine to treat tuberculosis (such as rifabutin, rifampin, rifapentine, Mycobutin®, Priftin®, Rifadin®, or Rimactane®), or medicine for seizures (such as carbamazepine, phenobarbital, phenytoin, Dilantin®, or Tegretol®).

Warnings While Using This Medicine:

  • Women who are pregnant or may become pregnant should avoid touching or handling this medicine. This medicine can get into the body through the skin and may harm an unborn male baby.
  • Make sure your doctor knows if you have kidney disease, liver disease, anemia, diarrhea, dehydration, neutropenia (low white blood cells), an infection, thrombocytopenia (low platelets in the blood), or a weak immune system.
  • This medicine may make you bleed, bruise, or get infections more easily. Take precautions to prevent illness and injury. Avoid people who are ill, and wash your hands often. Brush and floss your teeth gently, do not play rough sports, and be careful with sharp objects.
  • This medicine may cause serious allergic reactions. Tell your doctor right away if you start to have a cough; dizziness; wheezing; trouble with breathing; chest or throat tightness; swelling in your face or hands; fever; chills; rash; itching or hives; skin redness; or lightheadedness or faintness while you are receiving this medicine.
  • Cancer medicines can cause diarrhea, nausea, or vomiting in most people, sometimes even after receiving medicines to prevent it. Ask your doctor or nurse about other ways to control these side effects.
  • Your doctor will check your progress and the effects of this medicine at regular visits. Keep all appointments. Blood tests may be needed to check for side effects.

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Decrease in how much or how often you urinate, difficult or painful urination.
  • Fever, chills, cough, sore throat, and body aches.
  • Lightheadedness or fainting.
  • Numbness, tingling, or burning pain in your hands, arms, legs, or feet.
  • Pain, itching, burning, swelling, or a lump under your skin where the needle is placed.
  • Red or dark brown urine.
  • Shortness of breath or troubled breathing.
  • Swelling in your hands, ankles, or feet.
  • Unusual bleeding, bruising, or weakness.

If you notice these less serious side effects, talk with your doctor:

  • Back pain.
  • Bad or unusual taste in your mouth.
  • Diarrhea, constipation, nausea, vomiting, or stomach pain or upset.
  • Hair loss.
  • Headache or dizziness.
  • Joint or muscle pain.
  • Loss of appetite.
  • Sores, ulcers, or white patches in the mouth.
  • Weight loss.

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088


Last Updated: 7/4/2014


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