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Olmesartan/amlodipine/hydrochlorothiazide (By mouth)

Amlodipine (am-LOE-di-peen), Hydrochlorothiazide (hye-droe-klor-oh-THYE-a-zide), Olmesartan (ol-me-SAR-tan)

Treats high blood pressure. A lower blood pressure can reduce the risk of stroke and heart attack. This medicine contains an angiotensin receptor blocker (ARB), a calcium channel blocker (CCB), and a thiazide diuretic (water pill).

Brand Name(s):

There may be other brand names for this medicine.

When This Medicine Should Not Be Used:

Do not use this medicine if you have had an allergic reaction to olmesartan, amlodipine, hydrochlorothiazide, or a sulfonamide (sulfa) drug, or if you are pregnant. Do not use this medicine if you are not able to urinate. Do not use this medicine together with aliskiren (Tekturna®) if you have diabetes.

How to Use This Medicine:

Tablet

  • Take your medicine as directed. Your dose may need to be changed several times to find what works best for you.
  • Take this medicine at the same time each day.
  • Carefully follow your doctor's instructions about any special diet. Drink plenty of fluids if you exercise, sweat more than usual, or have diarrhea or vomiting.
  • Read and follow the patient instructions that come with this medicine. Talk to your doctor or pharmacist if you have any questions.

If a dose is missed:

  • Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.

How to Store and Dispose of This Medicine:

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.
  • Ask your pharmacist, doctor, or health caregiver about the best way to dispose of any outdated medicine or medicine no longer needed.
  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Make sure your doctor knows if you also use simvastatin (Vytorin®, Zocor®) or other medicine to lower cholesterol (such as cholestyramine, colesevelam, colestipol, Colestid®, Questran®). Also tell your doctor if you take a diuretic (water pill, such as furosemide, hydrochlorothiazide, torsemide, Aldactone®, Demadex®, Lasix®, Zaroxolyn®) or other blood pressure medicine (such as aliskiren, benazepril, enalapril, lisinopril, Avalide®, Avapro®, Benicar®, Cozaar®, Diovan®, Lotrel®, Micardis®, Tekturna®, Vasotec®, Zestril®, Zestoretic®).
  • Make sure your doctor knows if you also use lithium (Eskalith®, Lithobid®), an NSAID pain or arthritis medicine (such as aspirin, diclofenac, ibuprofen, naproxen, Advil®, Aleve®, Celebrex®, Voltaren®), insulin or an oral diabetes medicine (such as glimepiride, glyburide, metformin, Actos®, Janumet®, Januvia®), or a steroid medicine (such as hydrocortisone, methylprednisolone, prednisolone, prednisone).
  • If you also take colesevelam (Welchol®), take it at least 4 hours after you take Tribenzor®.
  • Ask your doctor before you use any medicine, supplement, or salt substitute that contains potassium.
  • Alcohol, narcotic pain medicine, or sleeping pills may cause you to feel more lightheaded, dizzy, or faint when used with this medicine.

Warnings While Using This Medicine:

  • It is not safe to take this medicine during pregnancy. It could harm an unborn baby. Tell your doctor right away if you become pregnant.
  • Make sure your doctor knows if you are breastfeeding or if you have had a heart attack. Tell your doctor if you have kidney problems, liver disease (including cirrhosis), diabetes, glaucoma, gout, lupus, congestive heart failure, heart or blood vessel disease, a mineral imbalance (such as high calcium or low potassium, magnesium, or sodium in the blood), or a history of allergies or asthma.
  • This medicine could lower your blood pressure too much and cause you to feel dizzy or lightheaded. Stand or sit up slowly if you are dizzy. This is more likely to happen when you begin to use the medicine or if you become dehydrated.
  • This medicine may make you drowsy. Do not drive, use machines, or do anything else that could be dangerous until you know how this medicine affects you.
  • Check with your doctor right away if you have chest pain that is worse than usual, trouble breathing, nausea, faintness, unusual sweating, or pain in your arm, jaw, back, or neck. This medicine may worsen the symptoms of an existing heart problem.
  • Check with your doctor immediately if you have vision changes, such as blurred vision, trouble reading, or eye pain, during or after treatment. This could be a sign of a serious eye problem.
  • Severe chronic diarrhea with weight loss may develop months to years after you start taking this medicine. Tell your doctor right away if you have these symptoms.
  • Do not stop using the medicine without asking your doctor, even if you feel well. This medicine will not cure your high blood pressure, but it will help keep it in the normal range. You may have to take blood pressure medicine for the rest of your life.
  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Blurred vision or changes in vision, eye pain
  • Change in how much or how often you urinate, bloody or cloudy urine
  • Chest pain that may spread to your arms, jaw, back, or neck, trouble breathing, nausea, unusual sweating
  • Confusion, weakness, and muscle twitching
  • Dry mouth, increased thirst, muscle cramps, nausea, vomiting
  • Fast, slow, or uneven heartbeat
  • Lightheadedness, dizziness, or fainting
  • Rapid weight gain, swelling in your hands, ankles, or feet
  • Severe diarrhea with weight loss

If you notice these less serious side effects, talk with your doctor:

  • Headache

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088


Last Updated: 9/4/2014


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