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Ticagrelor (By mouth)

Ticagrelor (tye-KA-grel-or)

This medicine is a blood thinner that may help prevent stroke, heart attack, and other heart and blood vessel problems.

Brand Name(s):

Brilinta

There may be other brand names for this medicine.

When This Medicine Should Not Be Used:

This medicine is not right for everyone. Do not use if you have had an allergic reaction to ticagrelor, or if you have active bleeding (such as a bleeding stomach ulcer or a head injury). Do not use this medicine if you have severe liver disease or a history of bleeding in your brain.

How to Use This Medicine:

Tablet

  • Take your medicine as directed.
  • You may take this medicine with or without food.
  • You may take this medicine with aspirin unless your doctor tells you otherwise. Do not use more than 100 milligrams per day of aspirin.
  • This medicine should come with a Medication Guide. Ask your pharmacist for a copy if you do not have one.
  • Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.
  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Make sure your doctor knows if you are also using medicine to treat HIV/AIDS (such as atazanavir, indinavir, nelfinavir, ritonavir, saquinavir, Crixivan®, Fortovase®, Invirase®, Norvir®, or Viracept®), medicine to treat an infection (such as clarithromycin, itraconazole, ketoconazole, telithromycin, voriconazole, Biaxin®, Ketek®, Nizoral®, or Sporanox®), medicine to treat tuberculosis (such as rifampin, Rifadin®, or Rimactane®), medicine to treat seizures (such as carbamazepine, phenobarbital, phenytoin, Dilantin®, Luminal®, or Tegretol®), medicine to treat depression (such as nefazodone, Serzone®), or a steroid medicine (such as dexamethasone, Decadron®, or Hexadrol®).
  • Talk with your doctor before taking aspirin, any other type of pain or arthritis medicine (such as diclofenac, etodolac, ibuprofen, indomethacin, naproxen, Advil®, Aleve®, Daypro®, Dolobid®, Feldene®, Indocin®, Motrin®, Naprosyn®, Orudis®, Relafen®, or Voltaren®), or other blood thinners (such as heparin, ticlopidine, warfarin, Coumadin®, Jantoven®, or Ticlid®). Tell your doctor if you are also using digoxin (Lanoxin®) or certain medicines to lower cholesterol (such as lovastatin, simvastatin, Altocor®, Mevacor®, or Zocor®).
  • If you are using this medicine for a condition called acute coronary syndrome, your doctor may tell you to take aspirin while you are using ticagrelor. In this case, do not change the dose or stop taking the aspirin without talking to your doctor first.

Warnings While Using This Medicine:

  • Make sure your doctor knows if you are pregnant or breastfeeding, or if you have liver disease, lung or breathing problems (such as asthma or COPD), or a history of bleeding problems. Tell your doctor if you plan to have surgery or a dental procedure.
  • While you are using this medicine, if you have any kind of bleeding, it may take longer than usual to stop, especially if you hurt yourself. Stay away from rough sports or other situations where you could be bruised, cut, or injured.
  • You may also have bleeding inside your body and not be aware of it. Tell your doctor if you have any unusual bleeding such as nosebleeds or blood in your urine or stools.
  • Tell any doctor or dentist who treats you that you are using this medicine. You may need to stop using this medicine several days before you have surgery or medical tests. Do not stop taking your medicine without your doctor's permission.
  • If you have unexpected or unexplained shortness of breath, trouble breathing, tightness in the chest, or wheezing, tell your doctor right away.
  • Do not stop using this medicine suddenly. Your doctor will need to slowly decrease your dose before you stop it completely. To do so may increase the chance of having a heart attack, blood clotting problems, or other serious conditions.
  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Bloody or black, tarry stools
  • Chest pain (not related to your disease)
  • Fast, slow, or pounding heartbeat
  • Lightheadedness, dizziness, or fainting
  • Nosebleeds
  • Problems with vision, speech, or walking
  • Red or dark brown urine
  • Shortness of breath or troubled breathing
  • Unusual bleeding or bruising
  • Unusual tiredness or weakness
  • Vomiting of blood like coffee grounds

If you notice these less serious side effects, talk with your doctor:

  • Back pain
  • Cough
  • Diarrhea
  • Headache

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088


Last Updated: 11/4/2014


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