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Brentuximab (Injection)

Brentuximab Vedotin (bren-TUX-i-mab ve-DOE-tin)

Treats cancer, including Hodgkin lymphoma (HL) and systemic anaplastic large cell lymphoma (sALCL).

Brand Name(s):

Adcetris

There may be other brand names for this medicine.

When This Medicine Should Not Be Used:

This medicine is not right for everyone. Do not use it if you had an allergic reaction to brentuximab or you are pregnant.

How to Use This Medicine:

Injectable

  • Medicines used to treat cancer are very strong and can have many side effects. Before receiving this medicine, make sure you understand all the risks and benefits. It is important for you to work closely with your doctor during your treatment.
  • You will receive this medicine while you are in a hospital or cancer treatment center. A nurse or other trained health professional will give you this medicine.
  • Your doctor will prescribe your dose and schedule. This medicine is given through a needle placed in a vein.
  • This medicine must be given slowly, so the needle will stay in place for 30 minutes. It is usually given every 3 weeks until your condition improves. You may also receive medicines to help prevent an allergic reaction.
  • Missed dose: Call your doctor or pharmacist for instructions.

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Do not take this medicine together with bleomycin.
  • Some medicines can affect how brentuximab works. Tell your doctor if you are taking ketoconazole or rifampin.

Warnings While Using This Medicine:

  • It is not safe to take this medicine during pregnancy. It could harm an unborn baby. Tell your doctor right away if you become pregnant.
  • Tell your doctor if you are breastfeeding or if you have kidney disease, liver disease, nerve problems, tumors, or any type of infection.
  • This medicine may cause the following problems:
    • Infusion reaction
    • Peripheral neuropathy
    • Progressive multifocal leukoencephalopathy (PML)
    • Tumor lysis syndrome
  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Blistering, peeling, red skin rash
  • Changes in mood, unusual behavior, confusion, dizziness
  • Change in how much or how often you urinate, painful or difficult urination
  • Chest pain within a few hours after you receive this medicine
  • Fever of 100.5 degrees F or higher, chills, sore throat
  • Numbness, tingling, or burning pain in your hands, arms, legs, or feet
  • Problems with vision, speech, thinking, or walking
  • Swelling in your face, feet, or lower legs
  • Trouble breathing
  • Unusual bleeding, bruising, tiredness, or weakness

If you notice these less serious side effects, talk with your doctor:

  • Diarrhea, nausea, vomiting, or stomach pain
  • Mild rash or itching skin

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088


Last Updated: 8/4/2014


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