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Brentuximab (Injection)

Brentuximab Vedotin (bren-TUX-i-mab ve-DOE-tin)

Treats Hodgkin's lymphoma (HL) and systemic anaplastic large cell lymphoma (sALCL).

Brand Name(s):

Adcetris

There may be other brand names for this medicine.

When This Medicine Should Not Be Used:

You should not receive this medicine if you have had an allergic reaction to brentuximab or if you are pregnant. Do not take this medicine together with bleomycin (Blenoxane®).

How to Use This Medicine:

Injectable

  • Medicines used to treat cancer are very strong and can have many side effects. Before receiving this medicine, make sure you understand all the risks and benefits. It is important for you to work closely with your doctor during your treatment.
  • You will receive this medicine while you are in a hospital or cancer treatment center. A nurse or other trained health professional will give you this medicine.
  • Your doctor will prescribe your dose and schedule. This medicine is given through a needle placed in a vein.
  • This medicine must be given slowly, so the needle will stay in place for 30 minutes. It is usually given every 3 weeks until your condition improves. You may also receive medicines to help prevent allergic reactions to the injection.

If a dose is missed:

  • Call your doctor or pharmacist for instructions.

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Make sure your doctor knows if you also use medicine to treat HIV/AIDS (such as indinavir, nelfinavir, ritonavir, saquinavir, Crixivan®, Fortovase®, Invirase®, Norvir®, or Viracept®), medicine to treat an infection (such as clarithromycin, itraconazole, ketoconazole, telithromycin, Biaxin®, Ketek®, Nizoral®, or Sporanox®), medicine to treat tuberculosis (such as rifampin, Rifadin®, Rimactane®), or nefazodone (Serzone®).

Warnings While Using This Medicine:

  • It is not safe to take this medicine during pregnancy. It could harm an unborn baby. Tell your doctor right away if you become pregnant.
  • Make sure your doctor knows if you are breastfeeding or if you have kidney disease, liver disease, nerve problems, tumors, or any type of infection.
  • Check with your doctor right away if you have burning, numbness, tingling, or painful sensations in your arms, hands, legs, or feet. These could be symptoms of peripheral neuropathy.
  • This medicine may cause an infusion reaction. Tell your doctor right away if you have a fever, chills, trouble breathing, rash, dizziness, or chest pain within a few hours after you receive it. This can be life-threatening and requires immediate medical attention.
  • Check with your doctor if you have a fever, chills, sore throat, or painful urination. These could be symptoms of an infection.
  • Call your doctor right away if you have a change in how much you urinate; joint pain; lower back, side, or stomach pain; swelling of the feet or lower legs; or unusual tiredness or weakness. These may be symptoms of a serious reaction called tumor lysis syndrome (TLS).
  • Serious allergic reactions can occur during treatment with this medicine. Check with your doctor right away if you have blistering, peeling, or loosening of the skin; rash; sores or ulcers on the skin; fever; or chills.
  • This medicine may cause a rare and serious brain infection called progressive multifocal leukoencephalopathy (PML). Check with your doctor right away if you have more than one of these symptoms: changes in vision, speech, or walking; memory loss; confusion; mood changes; or unusual tiredness or weakness.
  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Blistering, peeling, or red skin rash
  • Changes in mood, unusual behavior, or confusion
  • Chills, cough, runny or stuffy nose, sore throat, and body aches
  • Change in how much or how often you urinate, painful or difficult urination
  • Fever of 100.5 degrees F or greater
  • Numbness, tingling, or burning pain in your hands, arms, legs, or feet
  • Problems with vision, speech, thinking, or walking
  • Swelling in your face, feet, or lower legs
  • Trouble breathing
  • Unusual bleeding, bruising, tiredness, or weakness

If you notice these less serious side effects, talk with your doctor:

  • Diarrhea, nausea, vomiting, or stomach pain
  • Mild rash or itching skin

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088


Last Updated: 4/4/2014
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