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Brentuximab (Injection)

Brentuximab Vedotin (bren-TUX-i-mab ve-DOE-tin)

Treats cancer, including Hodgkin lymphoma and systemic anaplastic large cell lymphoma (sALCL).

Brand Name(s):

Adcetris

There may be other brand names for this medicine.

When This Medicine Should Not Be Used:

This medicine is not right for everyone. You should not receive it if you had an allergic reaction to brentuximab or you are pregnant.

How to Use This Medicine:

Injectable

  • You will receive this medicine while you are in a hospital or cancer treatment center. A nurse or other trained health professional will give you this medicine. It is usually given every 3 weeks.
  • Your doctor will prescribe your dose and schedule. This medicine is given through a needle placed in a vein.
  • Missed dose: Call your doctor or pharmacist for instructions.

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Do not use this medicine together with bleomycin.
  • Some medicines can affect how brentuximab works. Tell your doctor if you are using the following:
    • Ketoconazole
    • Rifampin

Warnings While Using This Medicine:

  • It is not safe to take this medicine during pregnancy. It could harm an unborn baby. Tell your doctor right away if you become pregnant.
  • Tell your doctor if you are breastfeeding, or if you have kidney disease, liver disease, or any type of infection.
  • This medicine may cause the following problems:
    • Peripheral neuropathy
    • Infusion reaction
    • Liver disease
    • Tumor lysis syndrome
    • Progressive multifocal leukoencephalopathy (a brain infection that can be life-threatening)
    • Serious skin reactions
  • This medicine may make you bleed, bruise, or get infections more easily. Take precautions to prevent illness and injury. Wash your hands often.
  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
  • Medicines used to treat cancer are very strong and can have many side effects. Before receiving this medicine, make sure you understand all the risks and benefits. It is important for you to work closely with your doctor during your treatment.

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Blistering, peeling, or red skin rash
  • Changes in mood, unusual behavior, confusion, dizziness
  • Chest pain, trouble breathing, or coughing up blood
  • Dark urine or pale stools, nausea, vomiting, loss of appetite, pain in your upper stomach, yellow skin or eyes
  • Fever of 100.5 degrees F or higher, chills, cough, sore throat, and body aches
  • Numbness, tingling, or burning pain in your hands, arms, legs, or feet
  • Pain or burning during urination, bloody or cloudy urine
  • Problems with vision, speech, thinking, or walking
  • Unusual bleeding, bruising, or weakness

If you notice these less serious side effects, talk with your doctor:

  • Diarrhea, nausea, vomiting, or stomach pain
  • Rash or itching
  • Tiredness

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088


Last Updated: 7/4/2015


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