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Ruxolitinib (By mouth)

Ruxolitinib (rux-oh-LI-ti-nib)

Treats myelofibrosis, a blood or bone marrow problem.

Brand Name(s):

Jakafi

There may be other brand names for this medicine.

When This Medicine Should Not Be Used:

Do not use this medicine if you have had an allergic reaction to ruxolitinib.

How to Use This Medicine:

Tablet

  • Take your medicine as directed. Your dose may need to be changed several times to find what works best for you.
  • This medicine can be given through a feeding tube for patients who are not able to swallow the tablet. Discuss this with your doctor, if needed.
  • If you receive a dialysis treatment, this medicine should be taken after the treatment.
  • Read and follow the patient instructions that come with this medicine. Talk to your doctor or pharmacist if you have any questions.

If a dose is missed:

  • Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.

How to Store and Dispose of This Medicine:

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.
  • Ask your pharmacist, doctor, or health caregiver about the best way to dispose of any outdated medicine or medicine no longer needed.
  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Make sure your doctor knows if you are also using conivaptan (Vaprisol®), nefazodone (Serzone®), medicine to treat hepatitis C infection (such as boceprevir, telaprevir, Incivek®, Victrelis®), medicine to treat an infection (such as clarithromycin, itraconazole, ketoconazole, posaconazole, telithromycin, voriconazole, Nizoral®), or medicine to treat HIV or AIDS (such as indinavir, lopinavir, nelfinavir, ritonavir, saquinavir, Crixivan®, Kaletra®, Norvir®).
  • Do not eat grapefruit or drink grapefruit juice while you are using this medicine.

Warnings While Using This Medicine:

  • Make sure your doctor knows if you are pregnant or breastfeeding, or if you have kidney disease or liver disease. Tell your doctor if you are on dialysis.
  • This medicine may make you bleed, bruise, or get infections more easily. Take precautions to prevent illness and injury. Avoid people who are ill, and wash your hands often. Brush and floss your teeth gently, do not play rough sports, and be careful with sharp objects.
  • Tell your doctor if you have any kind of infection before you start using this medicine.
  • This medicine may increase your risk of a serious brain infection called progressive multifocal leukoencephalopathy (PML). Call your doctor right away if you have weakness on one side of your body, loss of coordination, clumsiness, trouble seeing or speaking, memory problems, trouble thinking clearly, or loss of interest in things.
  • Do not stop using this medicine suddenly. Your doctor will need to slowly decrease your dose before you stop it completely.
  • If your condition does not improve within 6 months, or if it becomes worse, check with your doctor.
  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Clumsiness, weakness on one side of your body, trouble speaking, trouble seeing, confusion
  • Change in how much or how often you urinate, painful urination
  • Fever, chills, cough, sore throat, and body aches
  • Painful or burning skin rash or blisters
  • Tiny red dots on the skin, especially on the lower legs
  • Unusual bleeding or bruising
  • Unusual tiredness or weakness

If you notice these less serious side effects, talk with your doctor:

  • Dizziness
  • Headache
  • Weight gain

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088


Last Updated: 8/4/2014


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