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Aflibercept (Into the eye)

Aflibercept (a-FLIB-er-sept)

Treats neovascular (wet) age-related macular degeneration (AMD), macular edema after retinal vein occlusion, and diabetic macular edema (DME).

Brand Name(s):


There may be other brand names for this medicine.

When This Medicine Should Not Be Used:

This medicine is not right for everyone. You should not receive it if you had an allergic reaction to aflibercept, or if you have an eye infection or inflammation.

How to Use This Medicine:


  • A nurse or other health provider will give you this medicine.

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

Warnings While Using This Medicine:

  • Tell your doctor if you are pregnant or breastfeeding, or if you have glaucoma, other eye problems, or a history of blood clots, heart attack, or stroke.
  • This medicine may cause the following problems:
    • Increased risk for blood clots
    • Detached retina or endophthalmitis (swelling)
    • High pressure inside your eye
  • This medicine may cause temporary blurred vision. Do not drive or do anything that could be dangerous until you know how this medicine affects you.

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Bleeding in your eye
  • Blurred vision, seeing floating spots, flashes, or sparks of light
  • Chest pain, trouble breathing, coughing up blood
  • Eye pain, swelling or redness of your eyes or eyelids
  • Eye redness, sensitivity to light, halos around lights, vision changes
  • Numbness or weakness on one side of your body, sudden or severe headache
  • Pain in your calf, trouble walking or talking

If you notice these less serious side effects, talk with your doctor:

  • Watery eyes, feeling that something is in your eye

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088

Last Updated: 3/4/2015

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