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Bosutinib (By mouth)

Bosutinib (boe-SUE-ti-nib)

Treats chronic myeloid leukemia (CML). This is an antineoplastic (cancer) medicine.

Brand Name(s):

Bosulif

There may be other brand names for this medicine.

When This Medicine Should Not Be Used:

Do not use this medicine if you have had an allergic reaction to bosutinib, or if you are pregnant.

How to Use This Medicine:

Tablet

  • Medicines used to treat cancer are very strong and can have many side effects. Before receiving this medicine, make sure you understand all the risks and benefits. It is important for you to work closely with your doctor during your treatment.
  • Take your medicine as directed. Your dose may need to be changed several times to find what works best for you.
  • Swallow the tablet whole. Do not crush or break it, and do not handle broken tablets.
  • It is best to take this medicine with food or milk.

If a dose is missed:

  • Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose. If you miss a dose of this medicine and are more than 12 hours late, skip the missed dose and go back to your regular dosing schedule.

How to Store and Dispose of This Medicine:

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.
  • Ask your pharmacist, doctor, or health caregiver about the best way to dispose of any leftover medicine after you have finished your treatment. You will also need to throw away old medicine after the expiration date has passed.
  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Make sure your doctor knows if you use aprepitant (Emend®), bosentan (Tracleer®), conivaptan (Vaprisol®), modafinil (Provigil®), nefazodone (Serzone®), or St John's wort. Tell your doctor if you use a blood pressure medicine (such as diltiazem, verapamil, Cardizem®), medicine to treat seizures (such as carbamazepine, phenobarbital, phenytoin, Dilantin®, Tegretol®), or other cancer medicines (such as crizotinib, imatinib, Gleevec®, Xalkori®).
  • Make sure your doctor knows if you are also using medicine to treat bacterial infections (such as ciprofloxacin, clarithromycin, erythromycin, nafcillin, telithromycin, Biaxin®, Cipro®, Ery-Tab®), medicine to treat fungal infections (such as fluconazole, itraconazole, ketoconazole, posaconazole, voriconazole, Diflucan®, Nizoral®), medicine to treat tuberculosis (such as rifabutin, rifampin, Rifadin®, Rimactane®) medicine to treat HIV or AIDS (such as amprenavir, atazanavir, darunavir, efavirenz, etravirine, fosamprenavir, indinavir, nelfinavir, ritonavir, saquinavir, Crixivan®, Lexiva®, Norvir®, Prezista®, Reyataz®, Sustiva)®, or medicine to treat hepatitis C (such as boceprevir, telaprevir, Incivek®, Victrelis®).
  • Ask you doctor which stomach medicines are safe for you to take. Wait at least 2 hours before or after you take bosutinib. You should not take a proton pump inhibitor (PPI) such as lansoprazole, omeprazole, pantoprazole, Aciphex®, Dexilant®, Nexium®, Prevacid®, or Prilosec®.
  • Do not eat grapefruit or drink grapefruit juice while you are using this medicine.

Warnings While Using This Medicine:

  • It is not safe to take this medicine during pregnancy. It could harm an unborn baby. Tell your doctor right away if you become pregnant. Keep using birth control for at least 30 days after your last dose of this medicine.
  • Make sure your doctor knows if you are breastfeeding, or if you have liver disease, heart disease, or edema (fluid retention).
  • This medicine may make you bleed, bruise, or get infections more easily. Take precautions to prevent illness and injury. Avoid people who are ill, and wash your hands often. Brush and floss your teeth gently, do not play rough sports, and be careful with sharp objects.
  • Check with your doctor right away if you have stomach pain, pale stools or dark urine, loss of appetite, or yellow eyes or skin. These could be symptoms of a serious liver problem.
  • Check with your doctor if you have swelling, rapid weight gain, trouble breathing, chest pain, or cough. These may be signs of edema (retaining too much water).
  • This medicine can cause diarrhea, nausea, vomiting, or stomach pain. Ask your doctor about ways to control these side effects.
  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Dark-colored urine or pale stools, nausea, vomiting, loss of appetite, pain in your upper stomach, yellow skin or eyes
  • Fever, chills, cough, runny or stuffy nose, sore throat, and body aches
  • Rapid weight gain, swelling in your hands, ankles, or feet
  • Severe diarrhea, nausea, stomach pain, vomiting
  • Trouble breathing, chest pain, cough
  • Unusual bleeding, bruising, or weakness

If you notice these less serious side effects, talk with your doctor:

  • Diarrhea, nausea, vomiting, stomach pain, loss of appetite
  • Headache
  • Mild rash, fever

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088


Last Updated: 9/4/2014


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