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Pasireotide (Injection)

Pasireotide (pas-i-REE-oh-tide)

Treats Cushing disease.

Brand Name(s):

Signifor

There may be other brand names for this medicine.

When This Medicine Should Not Be Used:

Do not use this medicine if you have had an allergic reaction to pasireotide.

How to Use This Medicine:

Injectable

  • Take your medicine as directed. Your dose may need to be changed several times to find what works best for you.
  • Your doctor will prescribe your exact dose and tell you how often it should be given. This medicine is given as a shot under your skin. This medicine is usually injected under the skin of the thigh or stomach.
  • A nurse or other health provider will give you this medicine.
  • You may be taught how to give your medicine at home. Make sure you understand all instructions before giving yourself an injection. Do not use more medicine or use it more often than your doctor tells you to.
  • You will be shown the body areas where this shot can be given. Use a different body area each time you give yourself a shot. Keep track of where you give each shot to make sure you rotate body areas.
  • Use a new needle and syringe each time you inject your medicine.
  • You might not use all of the medicine in each ampul (glass container). Do not save an opened ampul. Do not use the medicine if it has changed color has particles floating in it.
  • This medicine should come with a Medication Guide. Ask your pharmacist for a copy if you do not have one.

If a dose is missed:

  • Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.

How to Store and Dispose of This Medicine:

  • If you store this medicine at home, keep it at room temperature, away from heat and direct light.
  • Ask your pharmacist, doctor, or health caregiver about the best way to dispose of any leftover medicine, containers, and other supplies. Throw away old medicine after the expiration date has passed.
  • Throw away used needles in a hard, closed container that the needles cannot poke through. Keep this container away from children and pets.
  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Make sure your doctor knows if you are also using medicine for heart rhythm problems (such as disopyramide, Norpace®, flecainide, Tambocor®, amiodarone, dofetilitde, Cordarone®, Tikosyn®) or blood pressure medicine (such as atenolol, metoprolol, propranolol, Bystolic®, Tenormin®, amlodipine, diltiazem, verapamil, Caduet®, Lotrel®).
  • Tell your doctor if you are also using bromocriptine (Parlodel®), cyclosporine (Gengraf®, Neoral®, Restasis®, Sandimmune®), or potassium or magnesium.

Warnings While Using This Medicine:

  • Make sure your doctor knows if you are pregnant or breastfeeding, or if you have liver disease. Tell your doctor if you have diabetes or a history of gallstones.
  • This medicine can affect your heart rhythm. Make sure your doctor knows if you have heart block, slow heartbeat, heart disease, heart rhythm problems (such as QT prolongation), heart failure, angina, history of heart attack, or low magnesium or potassium levels in your blood.
  • Contact your doctor right away if you have any changes to your heart rhythm. You might feel dizzy or faint, or you might have a slow, fast, pounding, or uneven heartbeat.
  • This medicine may cause low levels of cortisol in the blood (hypocortisolism). Tell your doctor right away if you have weakness, loss of appetite, nausea or vomiting, lightheadedness, dizziness, or fainting.
  • This medicine may raise your blood sugar, even if you do not have diabetes. You might need to have your blood sugar levels checked regularly.
  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Dry mouth, increased thirst, muscle cramps
  • Loss of appetite, nausea, vomiting
  • Fainting, dizziness, lightheadedness
  • Fast, pounding, or uneven heartbeat
  • Increased thirst, increase in how much or how often you urinate
  • Slow heartbeat
  • Unusual tiredness or weakness

If you notice these less serious side effects, talk with your doctor:

  • Diarrhea, constipation, stomach pain
  • Hair loss
  • Headache
  • Pain, itching, burning, swelling, or a lump under your skin where the shot is given
  • Stuffy or runny nose

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088


Last Updated: 8/4/2014


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