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Mipomersen (Injection)

Mipomersen (mi-poe-MER-sen)

Treats high cholesterol levels in people with homozygous familial hypercholesterolemia (HoHF).

Brand Name(s):

Kynamro

There may be other brand names for this medicine.

When This Medicine Should Not Be Used:

Do not use this medicine if you have had an allergic reaction to mipomersen, or if you have liver disease.

How to Use This Medicine:

Injectable

  • Your doctor will prescribe your exact dose and tell you how often it should be given. This medicine is given as a shot under your skin. This medicine is usually given once a week, on the same day. Do not inject this medicine into your muscle or vein.
  • You may be taught how to give your medicine at home. Make sure you understand all instructions before giving yourself an injection. Do not use more medicine or use it more often than your doctor tells you to.
  • You will be shown the body areas where this shot can be given. Use a different body area each time you give yourself a shot. Keep track of where you give each shot to make sure you rotate body areas. It is usually given in the stomach, thighs, or upper arms.
  • Use a new needle and syringe each time you inject your medicine.
  • The vial (glass container) or prefilled syringe should be removed from the refrigerator and allowed to reach room temperature for at least 30 minutes prior to injection. Do not remove the needle cover of the prefilled syringe until you are ready to give the shot.
  • Use each vial or syringe only one time. Do not save an open vial or syringe. Do not use the medicine if the solution looks cloudy or has floating particles in it. Return the medicine to the pharmacy if this occurs.
  • Do not inject the medicine on skin areas that have cuts, scrapes, infection, scars, rashes, sunburns, or tattoos.
  • This medicine should come with a Medication Guide. Ask your pharmacist for a copy if you do not have one.

If a dose is missed:

  • If you miss a dose of this medicine, use it as soon as you remember. If it is less than 3 days until your next regular dose, wait until then and skip the missed dose. Do not use extra medicine to make up for the missed dose.
  • Always allow at least 3 days between doses.

How to Store and Dispose of This Medicine:

  • If you store this medicine at home, keep it in the refrigerator. Do not freeze. You may also store the medicine at room temperature, away from heat and light, for up to 14 days. Keep your medicine in the original package until you are ready to use it.
  • Ask your pharmacist, doctor, or health caregiver about the best way to dispose of any leftover medicine, containers, and other supplies. Throw away old medicine after the expiration date has passed.
  • Throw away used needles in a hard, closed container that the needles cannot poke through. Keep this container away from children and pets.
  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Make sure your doctor knows if you are also using acetaminophen (Tylenol®), amiodarone (Cordarone®), isotretinoin (Accutane®), methotrexate (Rheumatrex®, Trexall®), tamoxifen (Nolvadex®), or a tetracycline antibiotic (such as doxycycline, minocycline, tetracycline, Solodyn®).
  • Do not drink more than one alcoholic drink per day while using this medicine.

Warnings While Using This Medicine:

  • Make sure your doctor knows if you are pregnant or breastfeeding. Use an effective form of birth control to keep from getting pregnant. Tell your doctor right away if you think you have become pregnant.
  • Tell your doctor if you have kidney problems, including high levels of protein in your urine.
  • Tell your doctor right away if you have pain or tenderness in the upper stomach, pale stools, dark urine, fever, loss of appetite, nausea, vomiting, or yellow eyes or skin. These could be symptoms of a serious liver injury.
  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Dark-colored urine or pale stools, nausea, vomiting, loss of appetite, pain in your upper stomach, yellow skin or eyes
  • Fever, itching, unusual tiredness or weakness

If you notice these less serious side effects, talk with your doctor:

  • Mild flu-like symptoms, fever, chills, muscle aches, body aches, tiredness
  • Pain, itching, burning, swelling, or a lump under your skin where the shot is given

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088


Last Updated: 8/4/2014


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