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Alogliptin/metformin (By mouth)

Alogliptin Benzoate (al-oh-GLIP-tin BEN-zoe-ate), Metformin Hydrochloride (met-FOR-min hye-droe-KLOR-ide)

Treats type 2 diabetes.

Brand Name(s):

Kazano

There may be other brand names for this medicine.

When This Medicine Should Not Be Used:

This medicine is not right for everyone. Do not use it if you had an allergic reaction to alogliptin or metformin, or if you have kidney disease or metabolic acidosis (including diabetic ketoacidosis).

How to Use This Medicine:

Tablet

  • Take your medicine as directed. Your dose may need to be changed several times to find what works best for you.
  • It is best to take this medicine with food or milk.
  • Swallow the tablet whole. Do not crush, break, or chew it.
  • This medicine should come with a Medication Guide. Ask your pharmacist for a copy if you do not have one.
  • Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.
  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Some medicines and food can affect how alogliptin/metformin works. Tell your doctor if you are taking any of the following:
    • Acetazolamide, cimetidine, dichlorphenamide, digoxin, isoniazid, morphine, phenytoin, procainamide, quinidine, quinine, ranitidine, topiramate, trimethoprim, vancomycin, zonisamide
    • Birth control pills, blood pressure medicine (such as amlodipine, atenolol, diltiazem, metoprolol, nifedipine, propranolol, verapamil), a diuretic (water pill, such as amiloride, furosemide, hydrochlorothiazide, torsemide, triamterene), estrogen hormones, insulin or other diabetes medicine (such as glimepiride, glipizide, glyburide, pioglitazone), a phenothiazine medicine (such as promethazine), a steroid medicine (such as hydrocortisone, methylprednisolone, prednisolone, prednisone), thyroid medicine (such as levothyroxine, liothyronine)
  • Do not drink excessive amounts of alcohol while you are taking this medicine.

Warnings While Using This Medicine:

  • Tell your doctor if you are pregnant or breastfeeding, or if you have liver disease, heart failure, gallstones, heart disease, anemia, vitamin B12 deficiency, or a history of alcohol abuse or pancreas problems. Tell your doctor if you recently had a fever, infection, injury, or surgery, or if you have a scheduled surgery.
  • Do not use this medicine to treat type 1 diabetes or diabetic ketoacidosis.
  • This medicine may cause the following problems:
    • A serious condition called lactic acidosis
    • Hypoglycemia (low blood sugar level), especially if you exercise more than normal or wait too long to eat
  • Drink plenty of fluids, especially if you exercise or are active in hot weather.
  • Make sure any doctor or dentist who treats you knows that you are using this medicine. This medicine may interact with the dye used for an x-ray or a CT scan.
  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Blistering, peeling, red skin rash
  • Change in how much or how often you urinate
  • Dark urine or pale stools, loss of appetite, stomach pain, yellow skin or eyes
  • Fast, slow, or pounding heartbeat
  • Lightheadedness or fainting
  • Rapid breathing, trouble breathing, nausea, and vomiting
  • Shaking, trembling, sweating, hunger, confusion
  • Sudden and severe stomach pain, nausea, vomiting, fever, and lightheadedness

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088


Last Updated: 8/4/2014


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