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Ado-trastuzumab emtansine (Injection)

Ado-Trastuzumab Emtansine (AY-doh tras-TOOZ-oo-mab em-TAN-seen)

Treats metastatic breast cancer.

Brand Name(s):

Kadcyla

There may be other brand names for this medicine.

When This Medicine Should Not Be Used:

This medicine is not right for everyone. You should not receive it if you had an allergic reaction to trastuzumab or ado-trastuzumab, or if you are pregnant.

How to Use This Medicine:

Injectable

  • Medicines used to treat cancer are very strong and can have many side effects. Before receiving this medicine, make sure you understand all the risks and benefits. It is important for you to work closely with your doctor during your treatment.
  • Your doctor will prescribe your dose and schedule. This medicine is given through a needle placed in a vein.
  • You will receive this medicine while you are in a hospital or cancer treatment center. A nurse or other trained health professional will give you this medicine.
  • This medicine is usually given once every 3 weeks.
  • Missed dose: This medicine needs to be given on a fixed schedule. If you miss a dose, call your doctor, home health caregiver, or treatment clinic for instructions.

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Some medicines can affect how ado-trastuzumab works. Tell your doctor if you are using any of the following:
    • Depression medicine, such as nefazodone
    • HIV/AIDS medicine, such as atazanavir, indinavir, nelfinavir, ritonavir, saquinavir
    • Infection medicine, such as clarithromycin, itraconazole, ketoconazole, telithromycin, voriconazole

Warnings While Using This Medicine:

  • This medicine can harm an unborn baby. Use an effective form of birth control to keep from getting pregnant during treatment and for 6 months after your last dose. Tell your doctor right away if you think you have become pregnant.
  • Tell your doctor if you are breastfeeding, or if you have liver disease, bleeding problems or low platelet count, heart failure, lung disease, or nerve problems.
  • This medicine may cause the following problems:
    • Serious liver problems
    • New or worsening heart failure
    • Infusion-related reactions
    • High risk of bleeding problems
  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Chest pain, fever, chills, trouble breathing, lightheadedness, dizziness, fast heartbeat
  • Coughing up blood, unusual nosebleeds
  • Dark urine or pale stools, nausea, vomiting, loss of appetite, stomach pain, yellow skin or eyes
  • Numbness, tingling, or burning pain in your hands, arms, legs, or feet
  • Pain, redness, itching, burning, swelling, or a lump under your skin where the needle is placed
  • Rapid weight gain, swelling in your hands, ankles, or feet
  • Unusual bleeding, bruising, or weakness

If you notice these less serious side effects, talk with your doctor:

  • Diarrhea, constipation
  • Muscle, joint, or bone pain

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088


Last Updated: 12/4/2014


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