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Dimethyl fumarate (By mouth)

Dimethyl Fumarate (dye-METH-il FUE-ma-rate)

Treats multiple sclerosis (MS).

Brand Name(s):

Tecfidera

There may be other brand names for this medicine.

When This Medicine Should Not Be Used:

Do not use this medicine if you have had an allergic reaction to dimethyl fumarate.

How to Use This Medicine:

Delayed Release Capsule

  • Take your medicine as directed.
  • You may take this medicine with or without food. You may have less skin flushing if you take the medicine with food.
  • Swallow the capsule whole. Do not crush or chew it. Do not sprinkle the contents of the capsule on food.
  • Read and follow the patient instructions that come with this medicine. Talk to your doctor or pharmacist if you have any questions.

If a dose is missed:

  • Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.

How to Store and Dispose of This Medicine:

  • Store the capsules in the original container away from heat, moisture, and direct light.
  • Ask your pharmacist, doctor, or health caregiver about the best way to dispose of any outdated medicine or medicine no longer needed. Once you have opened a bottle, throw away any unused medicine after 90 days.
  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

Warnings While Using This Medicine:

  • Make sure your doctor knows if you are pregnant or breastfeeding, or if you have lymphopenia or an infection.
  • This medicine may lower your white blood cell count, which could increase your risk of getting an infection. Avoid people with infections. Check with your doctor right away if you have a fever or chills, a cough, lower back or side pain, or painful or difficult urination.
  • This medicine may cause skin flushing, such as warmth, redness, or a burning sensation in your face, neck, arms, or upper chest. Check with your doctor if skin flushing occurs.
  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Fever or chills, cough, lower back or side pain, painful or difficult urination

If you notice these less serious side effects, talk with your doctor:

  • Diarrhea, nausea, vomiting, stomach pain
  • Skin rash or itching
  • Warmth or redness in your face, neck, arms, or upper chest

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088


Last Updated: 7/4/2014


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