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Brimonidine/brinzolamide (Into the eye)

Brimonidine Tartrate (bri-MOE-ni-deen TAR-trate), Brinzolamide (brin-ZOE-la-mide)

Lowers pressure inside the eye, which may be caused by glaucoma or hypertension of the eye.

Brand Name(s):

Simbrinza

There may be other brand names for this medicine.

When This Medicine Should Not Be Used:

Do not use this medicine if you have had an allergic reaction to brimonidine or brinzolamide. Make sure your doctor knows if you are allergic to sulfa drugs (sulfonamides).

How to Use This Medicine:

Liquid, Drop

  • Take your medicine as directed.
  • If you wear soft contact lenses, remove them before you use this medicine. Wait at least 15 minutes before you put the contact lenses back in.
  • Wash your hands with soap and water before and after using this medicine.
  • Shake the eye drops well just before each use.
  • Lie down or tilt your head back. With your index finger, pull down the lower lid of your eye to form a pocket.
  • To use the eye drops: Hold the dropper close to your eye with the other hand. Drop the correct number of drops into the pocket made between your lower lid and eyeball. Gently close your eyes. Place your index finger over the inner corner of your eye for 1 minute. Do not rinse or wipe the dropper or allow it to touch anything, including your eye. Put the cap on the bottle right away. Keep the bottle upright when you are not using it.
  • Do not use this medicine if the solution changes color or becomes cloudy.
  • Wait at least 5 minutes after you use this medicine before you use any other medicine in your eyes (drops or ointment).

If a dose is missed:

  • Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.

How to Store and Dispose of This Medicine:

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. You may also keep the medicine in the refrigerator. Do not freeze.
  • Ask your pharmacist, doctor, or health caregiver about the best way to dispose of the used medicine container and any leftover medicine after you have finished your treatment. You will also need to throw away old medicine after the expiration date has passed.
  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Make sure your doctor knows if you are using other medicine for glaucoma, such as acetazolamide (Diamox®), dorzolamide, or methazolamide (Neptazane®).
  • Make sure your doctor knows if you are also using aspirin, digoxin (Digitek®, Lanoxin®), medicine to lower blood pressure (such as amlodipine, atenolol, clonidine, hydrochlorothiazide, lisinopril, metoprolol, Benicar®, Cozaar®, Diovan®), medicine to treat depression (such as amitriptyline, nortriptyline, Elavil®), or an MAO inhibitor (such as Eldepryl®, Marplan®, Nardil®, Parnate®).
  • Alcohol, narcotic pain relievers, or sleeping pills may cause you to feel more dizzy or drowsy when used with this medicine.

Warnings While Using This Medicine:

  • Make sure your doctor knows if you are pregnant or breastfeeding, or if you have kidney disease, liver disease, depression, heart or blood vessel disease, low blood pressure, an eye infection, or other eye problems. Tell your doctor if you are allergic to sulfa drugs.
  • If your eyes or eyelids become red, itchy, or swollen when you use the drops, stop using the medicine and tell your doctor.
  • If you hurt your eye, develop an eye infection, or need to have eye surgery, talk with your doctor right away. You may need to change your medicine or stop using it.
  • This medicine may cause blurred vision for a short time. Be careful when driving, using machines, or doing anything else that could be dangerous if you cannot see properly.

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Blistering, peeling, or red skin rash
  • Ongoing or severe blurred vision or other changes in vision
  • Severe eye redness, pain, or swelling, sensitivity to light
  • Unusual bleeding, bruising, or weakness
  • Yellow skin or eyes

If you notice these less serious side effects, talk with your doctor:

  • Bitter, sour, or unusual taste, dry mouth
  • Blurred vision
  • Burning, dryness, itching, or stinging in the eyes
  • Drowsiness

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088


Last Updated: 9/4/2014


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