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Doxylamine/pyridoxine (By mouth)

Doxylamine Succinate (dox-IL-a-meen SUX-i-nate), Pyridoxine Hydrochloride (pir-i-DOX-een hye-droe-KLOR-ide)

Treats nausea and vomiting during pregnancy (also called morning sickness). This medicine is a combination of an antihistamine and vitamin B6.

Brand Name(s):

Diclegis

There may be other brand names for this medicine.

When This Medicine Should Not Be Used:

Do not use this medicine if you have had an allergic reaction to doxylamine, pyridoxine, or similar medicines (such as clemastine, dimenhydrinate, diphenhydramine, Benadryl®, Dramamine®). Do not use this medicine together with a MAO inhibitor (MAOI) such as Eldepryl®, Marplan®, Nardil®, or Parnate®. Do not use this medicine if you are breastfeeding.

How to Use This Medicine:

Delayed Release Tablet

  • Take your medicine as directed. Your dose may need to be changed several times to find what works best for you.
  • It is best to take this medicine on an empty stomach.
  • Swallow the tablet whole with a glass of water. Do not crush, break, or chew it.
  • Read and follow the patient instructions that come with this medicine. Talk to your doctor or pharmacist if you have any questions.

If a dose is missed:

  • Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.

How to Store and Dispose of This Medicine:

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.
  • Ask your pharmacist, doctor, or health caregiver about the best way to dispose of any outdated medicine or medicine no longer needed.
  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Tell your doctor if you drink alcohol or if you are using any medicine that makes you sleepy, such as allergy medicine or narcotic pain medicine.

Warnings While Using This Medicine:

  • Make sure your doctor knows if you have asthma, glaucoma, trouble urinating, or a stomach ulcer or other problems with your digestive system.
  • This medicine may make you drowsy or sleepy. Avoid driving, using machines, or doing anything else that could be dangerous until you know how this medicine affects you.
  • Call your doctor if your symptoms do not improve or if they get worse.
  • Your doctor will check your progress and the effects of this medicine at regular visits. Keep all appointments.

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Severe dizziness, lightheadedness, or sleepiness

If you notice these less serious side effects, talk with your doctor:

  • Dry mouth

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088


Last Updated: 8/4/2014


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