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Obinutuzumab (Injection)

Obinutuzumab (oh-bi-nue-TOOZ-ue-mab)

Treats chronic lymphocytic leukemia (CLL).

Brand Name(s):

Gazyva

There may be other brand names for this medicine.

When This Medicine Should Not Be Used:

This medicine is not right for everyone. You should not receive it if you had an allergic reaction to obinutuzumab.

How to Use This Medicine:

Injectable

  • Medicines used to treat cancer are very strong and can have many side effects. Before receiving this medicine, make sure you understand all the risks and benefits. It is important for you to work closely with your doctor during your treatment.
  • Your doctor will prescribe your dose and schedule. This medicine is given through a needle placed in a vein.
  • You will receive this medicine while you are in a hospital or cancer treatment center. A nurse or other trained health professional will give you this medicine.
  • Missed dose: This medicine needs to be given on a fixed schedule. If you miss a dose, call your doctor, home health caregiver, or treatment clinic for instructions.

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • This medicine may interfere with vaccines. Ask your doctor before you get a flu shot or any other vaccines.

Warnings While Using This Medicine:

  • Tell your doctor if you are pregnant or breastfeeding, or if you have low blood pressure, heart disease, lung problems, low white blood cell or platelet counts, an infection, or a history of hepatitis B infection.
  • This medicine may cause the following problems:
    • Reactivation of hepatitis B infection
    • A neuromuscular disease called progressive multifocal leukoencephalopathy (PML)
    • Infusion reactions
    • Tumor lysis syndrome, which can cause kidney problems
  • This medicine may make you bleed, bruise, or get infections more easily. Take precautions to prevent illness and injury. Wash your hands often.
  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Confusion, difficulty with walking or talking, vision problems
  • Dark urine or pale stools, nausea, vomiting, loss of appetite, stomach pain, yellow skin or eyes
  • Fever, chills, cough, sore throat, and body aches
  • Lightheadedness, dizziness, or fainting
  • Unusual bleeding, bruising, or weakness

If you notice these less serious side effects, talk with your doctor:

  • Pain, itching, burning, swelling, bleeding, or a lump under your skin where the needle is placed

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088


Last Updated: 11/4/2014


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